Drug–Polymer Electrostatic Complexes as New Structuring Agents for the Formation of Drug-Loaded Ordered Mesoporous Silica
| Autor: | Danielle Laurencin, Mélody Mathonnat, Emilie Molina, Jérôme Warnant, Patrick Lacroix-Desmazes, Corine Gérardin, Christine Jérôme, Maël Bathfield, Nathalie Marcotte, Martin In |
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| Přispěvatelé: | Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Laboratoire Charles Coulomb (L2C), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Matière Molle, Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), CERM |
| Rok vydání: | 2015 |
| Předmět: |
Polymers
Silicon dioxide Static Electricity Polyethylene Glycols chemistry.chemical_compound Electrochemistry Copolymer Organic chemistry General Materials Science Spectroscopy Acrylic acid chemistry.chemical_classification Drug Carriers Ethylene oxide [CHIM.MATE]Chemical Sciences/Material chemistry Surfaces and Interfaces Polymer Mesoporous silica Silicon Dioxide Condensed Matter Physics [CHIM.POLY]Chemical Sciences/Polymers Solubility chemistry Chemical engineering [PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci] Drug carrier Hybrid material |
| Zdroj: | Langmuir Langmuir, American Chemical Society, 2015, 31 (47), pp.12839-12844. ⟨10.1021/acs.langmuir.5b03221⟩ |
| ISSN: | 1520-5827 0743-7463 |
| Popis: | Using aminoglycoside antibiotics as drug models, it was shown that electrostatic complexes between hydrophilic drugs and oppositely charged double-hydrophilic block copolymers can form ordered mesophases. This phase behavior was evidenced by using poly(acrylic acid)-block-poly(ethylene oxide) block copolymers in the presence of silica precursors, and this allowed preparing drug-loaded mesoporous silica directly from the drug-polymer complexes. The novel synthetic strategy of the hybrid materials is highly efficient, avoiding waste and multistep processes; it also ensures optimal drug loading and provides pH-dependence of the drug release from the materials. |
| Databáze: | OpenAIRE |
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