The common genetic influence over processing speed and white matter microstructure: Evidence from the Old Order Amish and Human Connectome Projects

Autor:	Anderson M. Winkler, Laura M. Rowland, Thomas R. Coyle, Florian Muellerklein, Hemalatha Sampath, Jeffrey R. O'Connell, Mao Fu, George Eskandar, Thomas E. Nichols, Anya Savransky, Alan R. Shuldiner, Mary Morrissey, Braxton D. Mitchell, Paul M. Thompson, Xiaoming Du, Peter Kochunov, L. Elliot Hong, Christopher Gaudiot, Binish Patel, Neda Jahanshad
Rok vydání:	2015
Předmět:	Adult Male Adolescent Genotype Cognitive Neuroscience Brain mapping 050105 experimental psychology Article White matter 03 medical and health sciences Young Adult 0302 clinical medicine Cognition Genetic variation Fractional anisotropy Image Interpretation Computer-Assisted medicine Humans 0501 psychology and cognitive sciences Registries Aged Brain Mapping Human Connectome Project 05 social sciences Brain Heritability Middle Aged White Matter medicine.anatomical_structure Diffusion Tensor Imaging Phenotype Neurology Evolutionary biology Old Order Amish Anisotropy Female Psychology Amish Neuroscience 030217 neurology & neurosurgery Diffusion MRI
Zdroj:	NeuroImage. 125
ISSN:	1095-9572
Popis:	Speed with which brain performs information processing influences overall cognition and is dependent on the white matter fibers. To understand genetic influences on processing speed and white matter FA, we assessed processing speed and diffusion imaging fractional anisotropy (FA) in related individuals from two populations. Discovery analyses were performed in 146 individuals from large Old Order Amish (OOA) families and findings were replicated in 485 twins and siblings of the Human Connectome Project (HCP). The heritability of processing speed was h(2)=43% and 49% (both p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8e1157ad613abf443c6efc337f12720 https://pubmed.ncbi.nlm.nih.gov/26499807 Zobrazit plný text záznamu Full Text from ScienceDirect