Sex-Related Longitudinal Change of Motor, Non-Motor, and Biological Features in Early Parkinson's Disease
| Autor: | Nabila Dahodwala, Marina Picillo, Caroline M. Tanner, Rachel Sanders-Pullman, Susan Bressman, Amy W. Amara, Hyunkeun Ryan Cho, David-Erick Lafontant, Christopher S. Coffey, Chelsea Caspell-Garcia, Elliot Burghardt |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Biological Products Parkinson's disease business.industry Dopaminergic Sex related Parkinson Disease Disease Precision medicine medicine.disease Cellular and Molecular Neuroscience Cerebrospinal fluid Internal medicine Csf biomarkers medicine Disease Progression Non motor Humans Female Neurology (clinical) business Biomarkers |
| Zdroj: | Journal of Parkinson's disease. 12(1) |
| ISSN: | 1877-718X |
| Popis: | Background: Investigation of sex-related motor and non-motor differences and biological markers in Parkinson’s disease (PD) may improve precision medicine approach. Objective: To examine sex-related longitudinal changes in motor and non-motor features and biologic biomarkers in early PD. Methods: We compared 5-year longitudinal changes in de novo, untreated PD men and women (at baseline N = 423; 65.5%male) of the Parkinson’s Progression Markers Initiative (PPMI), assessing motor and non-motor manifestations of disease; and biologic measures in cerebrospinal fluid (CSF) and dopamine transporter deficit on DaTscanTM uptake. Results: Men experienced greater longitudinal decline in self-reported motor (p |
| Databáze: | OpenAIRE |
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