Sinusoidal Uptake Determines the Hepatic Clearance of Pevonedistat (TAK-924) as Explained by Extended Clearance Model

Autor:	Philip Sandoval, Bei-Ching Chuang, Lawrence Cohen, Tomoki Yoneyama, Sandeepraj Pusalkar, Robert W. Yucha, Swapan K Chowdhury, Paresh P. Chothe
Rok vydání:	2021
Předmět:	Pharmacology Pyrimidines Liver Pharmaceutical Science Cytochrome P-450 CYP3A Humans Membrane Transport Proteins Cyclopentanes Itraconazole Models Biological
Zdroj:	Drug metabolism and disposition: the biological fate of chemicals. 50(7)
ISSN:	1521-009X
Popis:	Quantitative assessment of hepatic clearance (CL
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8de9e5d222588a1c44038f7389db84d https://pubmed.ncbi.nlm.nih.gov/35545257 Zobrazit plný text záznamu