Diagnosis of rare subtypes of acute myeloid leukaemia and related neoplasms
| Autor: | Ashish Bajel, Tracy I. George |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Myeloid MECOM Chromosomal Proteins Non-Histone Acute basophilic leukemia Fusion Proteins bcr-abl Immunophenotyping Pathology and Forensic Medicine Cytogenetics 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine hemic and lymphatic diseases medicine Humans Poly-ADP-Ribose Binding Proteins Molecular Biology Oncogene Proteins Leukemia Myeloproliferative Disorders business.industry Prognosis medicine.disease MDS1 and EVI1 Complex Locus Protein GATA2 Transcription Factor Nuclear Pore Complex Proteins Leukemia Myeloid Acute 030104 developmental biology medicine.anatomical_structure RUNX1 chemistry 030220 oncology & carcinogenesis Immunology Acute panmyelosis with myelofibrosis Differential diagnosis business |
| Zdroj: | Pathology. 53:312-327 |
| ISSN: | 0031-3025 |
| DOI: | 10.1016/j.pathol.2021.02.001 |
| Popis: | The diagnosis of acute myeloid leukaemia and related neoplasms in adults is challenging as this requires the integration of clinical findings, morphology, immunophenotype, cytogenetics, and molecular genetic findings. Lack of familiarity with rare subtypes of acute leukaemia hinders the diagnosis. In this review, we will describe diagnostic findings of several rare acute myeloid leukaemias and related neoplasms that primarily occur in adults including information on presentation, morphology, immunophenotype, genetics, differential diagnosis, and prognosis. Leukaemias discussed include blastic plasmacytoid dendritic cell neoplasm, acute myeloid leukaemia with t(6;9) (p23;q34.1); DEK-NUP214, acute myeloid leukaemia with inv(3)(q21.3q26.2) or t(3;3)(q21.3;q26.2); GATA2, MECOM, acute myeloid leukaemia with BCR-ABL1, acute leukaemias of ambiguous lineage, acute myeloid leukaemia with mutated RUNX1, pure erythroid leukaemia, acute panmyelosis with myelofibrosis, and acute basophilic leukaemia. Case studies with morphological features of the nine subtypes of acute myeloid leukaemia and related neoplasms have been included, and additional evidence available since publication of the 2016 World Health Organization Classification has been added to each subtype. |
| Databáze: | OpenAIRE |
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