Prediction of in vivo supersaturation and precipitation of poorly water-soluble drugs: Achievements and aspirations
| Autor: | Naveen K. Thakral, Schwabe Robert J, Shirlynn Chen, Corinne Jankovsky, Laibin Luo, Eva Meister, Li Li |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
FOOD EFFECT
Supersaturation Computer science Pharmaceutical Science Water 02 engineering and technology 021001 nanoscience & nanotechnology 030226 pharmacology & pharmacy 03 medical and health sciences 0302 clinical medicine Water soluble Drug development Pharmaceutical Preparations Solubility In vivo Chemical Precipitation Biochemical engineering Pharmaceutical sciences 0210 nano-technology Predictive testing |
| Zdroj: | International journal of pharmaceutics. 600 |
| ISSN: | 1873-3476 |
| Popis: | This review focuses on options available to a pharmaceutical scientist to predict in vivo supersaturation and precipitation of poorly water-soluble drugs. As no single device or system can simulate the complex gastrointestinal environment, a combination of appropriate in vitro tools may be utilized to get optimal predictive information. To address the empirical issues encountered during small-scale and full-scale in vitro predictive testing, theoretical background and relevant case studies are discussed. The practical considerations for selection of appropriate tools at various stages of drug development are recommended. Upcoming technologies that have potential to further reduce in vivo studies and expedite the drug development process are also discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect