SLC6A4 polymorphisms modulate the efficacy of a tryptophan-enriched diet on age-related depression and social cognition

Autor: Ana Rodríguez, Thomas Plieger, Martin Reuter, Vera Zamoscik, Peter Kirsch, Lierni Ugartemendia, Rafael Bravo, M. Yolanda Castaño
Rok vydání: 2021
Předmět:
Male
Social Cognition
0301 basic medicine
medicine.medical_specialty
Genotype
Placebo-controlled study
030209 endocrinology & metabolism
Urine
Critical Care and Intensive Care Medicine
Placebo
Diet Surveys
Eating
Young Adult
03 medical and health sciences
0302 clinical medicine
Social cognition
Internal medicine
medicine
Humans
Genetic Predisposition to Disease
Nutritional Physiological Phenomena
Single-Blind Method
Alleles
Genetic Association Studies
Serotonin transporter
Depression (differential diagnoses)
Serotonin Plasma Membrane Transport Proteins
Psychological Tests
Polymorphism
Genetic
030109 nutrition & dietetics
Nutrition and Dietetics
biology
Depression
business.industry
Age Factors
Tryptophan
Hydroxyindoleacetic Acid
Middle Aged
Healthy Volunteers
Diet
biology.protein
Female
Empathy
business
Zdroj: Clinical Nutrition. 40:1487-1494
ISSN: 0261-5614
DOI: 10.1016/j.clnu.2021.02.023
Popis: Summary Background & aims In a placebo controlled study we sought to determine if a four-weeks tryptophan-enriched diet is able to improve age-related depression or social cognitive impairment, depending on polymorphisms located in the promoter region of Solute Carrier Family 6 Member 4 (SLC6A4), also known as serotonin transporter (SERT1) gene. Methods 91 young volunteers (age: 21 ± 2 yrs) and 127 above 50 years old (58 ± 6 yrs) healthy volunteers completed the study. Participants from the placebo and tryptophan group followed the same protocol. Before starting the study blood samples, to measure serotonin-transporter-linked polymorphic region (5-HTTLPR) and rs25531 polymorphisms, were collected. In addition, before and after completing the study urine samples (to measure 5-hydroxyindolacetic acid (5-HIAA) were taken, while psychological questionnaires (to assess depression and social cognition levels), and a one week dietary record (to calculate the tryptophan (TRP) intake) were assessed. Results The triallelic approach of SLC6A4 showed that in S'S´ subjects there was a positive correlation between TRP intake and 5-HIAA levels. Age of participants, SLC6A4 genotype, and experimental condition were important factors contributing to the outcome of depression and social cognition. Conclusions 5-HTTLPR and rs25531 polymorphisms play a key role in the response to the TRP- based nutritional intervention, improving only age-related depressive symptoms and empathy in S'S´ subjects who have a higher risk to show signs of depression during their lifetime.
Databáze: OpenAIRE
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