Marrow adiposity as an indicator for insulin resistance in postmenopausal women with newly diagnosed type 2 diabetes – an investigation by chemical shift-encoded water-fat MRI
| Autor: | Xu Zheng, Guanwu Li, Haiyang Lin, Xuefeng Li, Zhu Lequn, Xiao Shi, Shixin Chang, Ying Wang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Type 2 diabetes 030218 nuclear medicine & medical imaging 03 medical and health sciences chemistry.chemical_compound Absorptiometry Photon 0302 clinical medicine Insulin resistance Body Water Bone Marrow Internal medicine Diabetes mellitus medicine Homeostasis Humans Glucose homeostasis Radiology Nuclear Medicine and imaging Bone Marrow Diseases Adiposity Bone mineral Lumbar Vertebrae business.industry Insulin General Medicine Middle Aged medicine.disease Magnetic Resonance Imaging Postmenopause Cross-Sectional Studies Endocrinology Adipose Tissue Diabetes Mellitus Type 2 chemistry 030220 oncology & carcinogenesis Body Composition Lean body mass Female Glycated hemoglobin Insulin Resistance business |
| Zdroj: | European Journal of Radiology. 113:158-164 |
| ISSN: | 0720-048X |
| DOI: | 10.1016/j.ejrad.2019.02.020 |
| Popis: | Marrow fat accumulates in diabetic conditions but remains elusive. The published works on the relationships between marrow fat phenotypes and glucose homeostasis are controversial.To detect the association of insulin resistance with marrow adiposity in postmenopausal women with newly diagnosed type 2 diabetes (T2D) using chemical shift-encoded water-fat MRI.We measured vertebral proton density fat fraction (PDFF) by 3T-MRI in 75 newly diagnosed T2D and 20 nondiabetic postmenopausal women. Bone mineral density (BMD), whole body fat mass and lean mass were determined by dual-energy X-ray absorptiometry. Insulin sensitivity was estimated using the homeostasis model assessment of insulin resistance (HOMA-IR).Lumbar spine PDFF was higher in women with T2D (65.9 ± 6.8%) than those without diabetes (59.5 ± 6.1%, P = 0.009). There was a consistent inverse association between the vertebral PDFF and BMD. PDFF had a positive association with glycated hemoglobin and HOMA-IR but not with fasting plasma glucose and insulin. PDFF was significantly increased, and BMD was decreased in a linear trend from the lowest (1.90) to highest (≥2.77) HOMA-IR quartile. Multivariate linear regression analyses revealed a positive association between log-transformed HOMA-IR and PDFF after adjustment for multiple covariates (ß = 0.382, P 0.001). The positive association of HOMA-IR with PDFF remained robust when total body lean mass and fat mass, BMD was entered into the multivariate regression model, respectively (ß = 0.293 and ß = 0.251, respectively; all P0.05).Elevated HOMA-IR was linked to higher marrow fat fraction in postmenopausal women with newly diagnosed T2D independently of body compositions. |
| Databáze: | OpenAIRE |
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