Humoral responses to SARS-CoV-2 by healthy and sick dogs during the COVID-19 pandemic in Spain

Autor: Antonio Meléndez-Lazo, Beatriz Davinia Tomeo-Martín, Alicia Barbero-Fernández, Michaela Gentil, Pedro Plaza, Gustavo Ortiz-Diez, Paula Palau-Concejo, Pablo Delgado-Bonet, Jorge G. Gonzalez, Pablo Gómez-Ochoa, Ana Judith Perisé-Barrios, Javier García-Castro
Přispěvatelé: Fundación Universidad Alfonso X el Sabio, Comunidad de Madrid (España), Comunidad de Madrid, Universidad Alfonso X El Sabio, Instituto de Salud Carlos III [Madrid] (ISC)
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname
Veterinary Research
Repisalud
Instituto de Salud Carlos III (ISCIII)
Veterinary Research, BioMed Central, 2021, 52 (1), pp.22. ⟨10.1186/s13567-021-00897-y⟩
Zaguán: Repositorio Digital de la Universidad de Zaragoza
Universidad de Zaragoza
Veterinary Research, Vol 52, Iss 1, Pp 1-11 (2021)
ISSN: 0928-4249
1297-9716
DOI: 10.1186/s13567-021-00897-y⟩
Popis: COVID-19 is a zoonotic disease caused by SARS-CoV-2. Infections of animals with SARS-CoV-2 have recently been reported, and an increase of severe lung pathologies in domestic dogs has also been detected by veterinarians in Spain. Therefore, further descriptions of the pathological processes in those animals that show symptoms similar to those described in humans affected by COVID-19 would be highly valuable. The potential for companion animals to contribute to the continued transmission and community spread of this known human-to-human disease is an urgent issue to be considered. Forty animals with pulmonary pathologies were studied by chest X-ray, ultrasound analysis, and computed tomography. Nasopharyngeal and rectal swabs were analyzed to detect canine pathogens, including SARS-CoV-2. An additional twenty healthy dogs living in SARS-CoV-2-positive households were included. Immunoglobulin detection by several immunoassays was performed. Our findings show that sick dogs presented severe alveolar or interstitial patterns with pulmonary opacity, parenchymal abnormalities, and bilateral lesions. The forty sick dogs were negative for SARS-CoV-2 but Mycoplasma spp. was detected in 26 of 33 dogs. Five healthy and one pathological dog presented IgG against SARS-CoV-2. Here we report that despite detecting dogs with α-SARS-CoV-2 IgG, we never obtained a positive RT-qPCR for SARS-SoV-2, not even in dogs with severe pulmonary disease; suggesting that even in the case of canine infection, transmission would be unlikely. Moreover, dogs living in COVID-19-positive households could have been more highly exposed to infection with SARS-CoV-2. Study funded by Fundación Universidad Alfonso X el Sabio (1.011.115 grant to A.J.P-B.; 1.011.101 to A.B-F.) and Comunidad de Madrid (COV20/01398 grant to A.J.P-B. and A.B-F.). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Sí
Databáze: OpenAIRE
Externí odkaz: