A 12-month study of the effects of oral zidovudine on neurodevelopmental functioning in a cohort of vertically HIV-infected inner-city children
| Autor: | Andrew Wiznia, Y. St Louis, M. Hoberman, J. Dobroszycki, S. Arpadi, Molly L. Nozyce, Genevieve Lambert, Chee Jen Chang |
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| Rok vydání: | 1994 |
| Předmět: |
CD4-Positive T-Lymphocytes
Male Pediatrics medicine.medical_specialty Urban Population Developmental Disabilities Immunology HIV Infections Neuropsychological Tests Cohort Studies Leukocyte Count Zidovudine Acquired immunodeficiency syndrome (AIDS) Immunopathology medicine Humans Immunology and Allergy Outpatient clinic Child Sida Poverty biology business.industry Body Weight Infant Hispanic or Latino biology.organism_classification medicine.disease Body Height Surgery Black or African American Treatment Outcome Infectious Diseases Socioeconomic Factors El Niño Child Preschool Cohort Female New York City Viral disease Psychomotor Disorders Cognition Disorders business medicine.drug |
| Zdroj: | AIDS. 8:635-640 |
| ISSN: | 0269-9370 |
| Popis: | OBJECTIVE To examine the effects of oral zidovudine on the neurodevelopmental functioning of HIV-infected children. METHODS Oral zidovudine was administered to 54 symptomatic children with vertically transmitted HIV infection (Centers for Disease Control and Prevention class P2). All children were recruited from an inner-city pediatric HIV/AIDS outpatient clinic and ranged in age from 2 months to 12 years and 11 months (mean age, 3 years) at entry. Neurodevelopmental functioning, height and weight, and lymphocyte subpopulation data were ascertained for all the children pretherapy, and 6 and 12 months post-therapy initiation. RESULTS Analysis of the 6- and 12-month post-initiation drug data found no significant change in neurodevelopmental functioning. Height and weight percentiles remained the same or improved in the majority of children. CD4+ cell counts declined over the treatment period with CD4+ counts < 500 x 10(6)/l observed in 15% of the children pre-therapy, and 33% after 1 year. CONCLUSION In contrast with previously published data, the present study observed no improvement in neurodevelopmental functioning in HIV-infected children treated with oral zidovudine. |
| Databáze: | OpenAIRE |
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