Inhibition of furosemide-induced renin release by vasoconstrictors
| Autor: | Georg Hertting, Dieter K. Meyer, B. Lauterwein, H. Boll |
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| Rok vydání: | 1975 |
| Předmět: |
Male
Octapressin medicine.medical_specialty Renin secretion Stimulation Kidney Phenylephrine Furosemide Internal medicine Renin Renin–angiotensin system medicine Animals Vasoconstrictor Agents Felypressin Pharmacology Chemistry Aminohippuric Acids Angiotensin II General Medicine Rats Endocrinology Regional Blood Flow Renal blood flow medicine.drug |
| Zdroj: | Naunyn-Schmiedeberg's Archives of Pharmacology. 290:307-314 |
| ISSN: | 1432-1912 0028-1298 |
| DOI: | 10.1007/bf00510559 |
| Popis: | The effect of i.v. infused (asp1-beta-amid, val5)-angiotensin II (1.0 mug/kg min), octapressin (phe2, lys8-vasopressin) (10.0 mU/kg min) and of the alpha-sympathomimetic amine phenylephrine (40.0 mug/kg min) on the stimulation of renin secretion by furosemide (10.0 mg/kg i.v.) was investigated. The vasoconstrictors abolished the renin release induced by forosemide. Studies on the clearance of p-aminohippuric acid (PAH) (i.e. renal plasma flow) showed that the action of the vasoconstrictors cannot be explained by a decrease in access of furosemide to its intrarenal sites of action. The mechanism of the suppressive action of the vasoconstrictors on renin release is discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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