Cortisol?cortisone ratios in small for gestational age (SGA) children without postnatal catch-up growth
| Autor: | Hartmut A. Wollmann, Jörg Dötsch, Udo Meissner, Wolfgang Rascher, Helmuth-Günther Dörr, Manfred Rauh, Christian Plank |
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| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Hydrocortisone Endocrinology Diabetes and Metabolism Short stature Fetal Development Endocrinology Pregnancy Internal medicine medicine Animals Humans Risk factor Child Growth Disorders reproductive and urinary physiology business.industry Infant Newborn Case-control study Gestational age medicine.disease Rats Cortisone Cross-Sectional Studies Case-Control Studies Child Preschool Infant Small for Gestational Age Linear Models Small for gestational age Female medicine.symptom business Infant Premature medicine.drug |
| Zdroj: | Clinical Endocrinology. 67:304-309 |
| ISSN: | 1365-2265 0300-0664 |
| Popis: | Summary Objective Low birthweight is a risk factor for metabolic and cardiovascular disorders in later adult life. Changes in the activity of 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) and the consequent disequilibrium between cortisol (F) and cortisone (E) are thought to be a key mechanism for these effects. We investigated whether prenatal programming leads to alterations in F/E ratios on a systemic level. Design, patients and methods In a cross-sectional, retrospective study we analysed sera of 132 children born small for gestational age (SGA) (aged 2–13 years) with persistent short stature [ |
| Databáze: | OpenAIRE |
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