Synthesis and antibacterial activity of novel lincomycin derivatives. I. Enhancement of antibacterial activities by introduction of substituted azetidines

Autor:	Eijiro Umemura, Yoshinari Wakiyama, Ko Kumura, Kazutaka Ueda, Hideki Fushimi, Takashi Watanabe, Keiichi Ajito, Eiki Shitara, Takuji Yoshida
Rok vydání:	2016
Předmět:	0301 basic medicine Streptococcus pyogenes Antiparasitic medicine.drug_class Stereochemistry 030106 microbiology Biology medicine.disease_cause 01 natural sciences Beta-lactam Structure-Activity Relationship 03 medical and health sciences chemistry.chemical_compound Biosynthesis Drug Discovery Streptococcus pneumoniae medicine Pharmacology 010405 organic chemistry biochemical phenomena metabolism and nutrition Combinatorial chemistry Glycopeptide Anti-Bacterial Agents Lincomycin 0104 chemical sciences chemistry Genes Bacterial Azetidines Antibacterial activity medicine.drug
Zdroj:	The Journal of Antibiotics. 69:440-445
ISSN:	1881-1469 0021-8820
DOI:	10.1038/ja.2015.134
Popis:	The synthesis and antibacterial activity of (7S)-7-sulfur-azetidin-3-yl lincomycin derivatives are described. Modification was achieved by a simple reaction of (7R)-7-O-methanesulfonyllincomycin and the corresponding substituted azetidine-2-thiol. Several compounds first showed moderate antibacterial activity against Streptococcus pneumoniae and Streptococcus pyogenes with erm gene as lincomycin derivatives.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8d30e339fef0c158e12c0979528c074 https://doi.org/10.1038/ja.2015.134 Zobrazit plný text záznamu Full text from SpringerLink