Adiabatic pulses in1H-15N direct and long-range heteronuclear correlations
| Autor: | Chad E. Hadden |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Magnetic Resonance Spectroscopy
Molecular Structure Nitrogen Isotopes Chemistry Spectral window Analytical chemistry General Chemistry Reference Standards Sensitivity and Specificity Molecular physics Heteronuclear molecule Computer Simulation General Materials Science Protons Adiabatic process Nizatidine |
| Zdroj: | Magnetic Resonance in Chemistry. 43:330-333 |
| ISSN: | 1097-458X 0749-1581 |
| Popis: | The application of adiabatic inversion pulses to the detection of 1H–15N heteronuclear correlations is described. The pulse sequences studied were gHSQC, CRISIS-gHSQC, gHMBC and CRISIS-gHMBC. The poor inversion quality of rectangular 180° X pulses can lead to a loss of signal at the peripheries of the spectrum. Replacing these pulses with adiabatic sweeps significantly improves sensitivity across the potentially large 15N spectral window. Satellite spectrum profiles are shown to demonstrate the increase in sensitivity when employing adiabatic pulses on wide spectral widths. Additionally, the active pharmaceutical nizatidine was used as a model compound to demonstrate the improvements in the long-range correlation data. Copyright © 2004 John Wiley & Sons, Ltd. |
| Databáze: | OpenAIRE |
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