Homologous protein domains in SARS-CoV-2 and measles, mumps and rubella viruses: preliminary evidence that MMR vaccine might provide protection against COVID-19
| Autor: | Yorgo Modis, Amir Reyahi, Robin J.M. Franklin, Rocio Fernandez Mendez, Alexis J Joannides, Adam Young, Bjoern Neumann |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0303 health sciences
business.industry Rubella virus Disease medicine.disease_cause medicine.disease MMR vaccine Rubella Measles Virology 3. Good health Vaccination 03 medical and health sciences 0302 clinical medicine Immunity Pandemic medicine 030212 general & internal medicine business 030304 developmental biology |
| DOI: | 10.1101/2020.04.10.20053207 |
| Popis: | The COVID-19 disease is one of worst pandemics to sweep the globe in recent times. It is noteworthy that the disease has its greatest impact on the elderly. Herein, we investigated the potential of childhood vaccination, specifically against measles, mumps and rubella (MMR), to identify if this could potentially confer acquired protection over SARS-CoV-2. We identified sequence homology between the fusion proteins of SARS-CoV-2 and measles and mumps viruses. Moreover, we also identified a 29% amino acid sequence homology between the Macro (ADP-ribose-1’’-phosphatase) domains of SARS-CoV-2 and rubella virus. The rubella Macro domain has surface-exposed conserved residues and is present in the attenuated rubella virus in MMR. Hence, we hypothesize that MMR could protect against poor outcome in COVID-19 infection. As an initial test of this hypothesis, we identified that 1) age groups that most likely lack of MMR vaccine-induced immunity had the poorest outcome in COVID-19, and 2) COVID-19 disease burden correlates with rubella antibody titres, potentially induced by SARS-CoV2 homologous sequences. We therefore propose that vaccination of ‘at risk’ age groups with an MMR vaccination merits further consideration as a time appropriate and safe intervention. |
| Databáze: | OpenAIRE |
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