Human intestinal parasites in Mahajanga, Madagascar: The kingdom of the protozoa
| Autor: | Bruno Pereira, Valentin Greigert, Rivo Solotiana Rakotomalala, Milijaona Randrianarivelojosia, Ermanno Candolfi, Julie Brunet, Jean-Louis Razafindrakoto, Alexander W. Pfaff, Ahmed Abou-Bacar, Eugene Morel, Céline Nourrisson, Philippe Poirier, Leila Benarbia |
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| Přispěvatelé: | Hôpital pasteur [Colmar], Institut de Parasitologie et de Pathologie Tropicale (IPPTS), Université de Strasbourg (UNISTRA), Laboratoire de Parasitologie et de Mycologie Médicale [Strasbourg], Les Hôpitaux Universitaires de Strasbourg (HUS), Laboratoire Microorganismes : Génome et Environnement (LMGE), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Centre National de la Recherche Scientifique (CNRS)-Université d'Auvergne - Clermont-Ferrand I (UdA), Laboratoire de Parasitologie et Mycologie [CHU Clermont-Ferrand], CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Direction de la recherche clinique et de l’innovation [CHU Clermont-Ferrand] (DRCI), CHU Clermont-Ferrand, Unité de Recherche sur le Paludisme [Antananarivo, Madagascar], Institut Pasteur de Madagascar, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), CHU PZaga [Mahajanga, Madagascar], CHU Mahavoky Atsimo [Mahajanga, Madagascar], Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Rural Population Veterinary medicine Urban Population lcsh:Medicine 0302 clinical medicine Intestinal Parasites MESH: Rural Population [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases Genotype Prevalence Medicine and Health Sciences Prospective Studies Geography Medical Intestinal Diseases Parasitic Sanitation lcsh:Science MESH: Phylogeny Dientamoeba fragilis Phylogeny 2. Zero hunger Protozoans education.field_of_study Multidisciplinary biology MESH: Dientamoeba/genetics Eukaryota 3. Good health MESH: Urban Population Microsporidia MESH: Intestinal Diseases Parasitic/diagnosis Female MESH: Blastocystis Research Article Adult Dientamoeba Fragilis MESH: Madagascar/epidemiology MESH: Protozoan Infections/epidemiology 030231 tropical medicine Population MESH: Intestinal Diseases Parasitic/epidemiology 03 medical and health sciences Population Metrics Protozoan infection MESH: Geography Medical parasitic diseases medicine Madagascar Parasitic Diseases MESH: Cities Helminths Humans MESH: Sanitation [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology Sex Ratio Cities education Dientamoeba MESH: Prevalence Blastocystis Protozoan Infections MESH: Humans Population Biology MESH: Protozoan Infections/diagnosis lcsh:R Organisms Biology and Life Sciences MESH: Adult biology.organism_classification medicine.disease Parasitic Protozoans MESH: Male MESH: Prospective Studies 030104 developmental biology Protozoa lcsh:Q Parasitology Parasitic Intestinal Diseases MESH: Female |
| Zdroj: | PLoS ONE PLoS ONE, Public Library of Science, 2018, 13 (10), pp.e0204576. ⟨10.1371/journal.pone.0204576⟩ PLoS ONE, 2018, 13 (10), pp.e0204576. ⟨10.1371/journal.pone.0204576⟩ PLoS ONE, Vol 13, Iss 10, p e0204576 (2018) |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0204576⟩ |
| Popis: | International audience; INTRODUCTION: Intestinal parasitic infections are a major public health problem in inter-tropical areas. The aim of our study was to describe the situation in Mahajanga, Madagascar with a particular focus on two protozoa, Dientamoeba fragilis and Blastocystis sp.METHODS: This was a prospective study from February to June 2015. Stool samples from symptomatic hospitalized patients and asymptomatic volunteers were submitted to microscopy and molecular assays in order to detect parasites.RESULTS: A wide panel of intestinal parasites were identified among the 265 included subjects, protozoa being the most prevalent with 72.8% whereas the prevalence of helminths and microsporidia was of 7.9% and 4.5%, respectively. Blastocystis sp. was the most prevalent protozoa (64.5% of the entire cohort) followed by various amoebas (35.5%) and flagellates (27,5%). We only detected subtypes 1, 2 and 3 of Blastocystis sp. Among the patients positive for D. fragilis (9.4%), 23 carried genotype 1 and 1 genotype 2. For the first time, we detected in 4 human stools the DNA of a recently described protozoon, Simplicimonas similis. Interestingly, subjects living in urban areas harbored significantly more different parasitic species than subjects living in rural areas with a correlation between sanitary level of neighborhood and protozoan infection. However, there was no difference in prevalence of digestive symptoms between parasite-free and parasite-infected subjects, except for Giardia intestinalis which had more symptomatic carriers.DISCUSSION: Our study reveals a high overall parasite prevalence, similar to what had been found in 2003 in the same city and to other prevalence studies conducted in Africa. The poor access of the population to sanitary infrastructures may explain this result. Data from our study provide valuable key for sanitation programs and prevention of fecal-related infectious diseases. |
| Databáze: | OpenAIRE |
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