Acute administration of capsaicin increases resting energy expenditure in young obese subjects without affecting energy intake, appetite, and circulating levels of orexigenic/anorexigenic peptides
| Autor: | Laura Abbruzzese, Silvano G. Cella, Gabriella Tringali, Antonello E. Rigamonti, Sofia Tamini, C. Casnici, Elisa Lucchetti, Alessandra De Col, Mauro Bortolotti, Ornella Marelli, Alessandro Sartorio, Roberta De Micheli |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Adolescent Hunger Endocrinology Diabetes and Metabolism media_common.quotation_subject Population Appetite Satiety Response Young Adult 03 medical and health sciences Endocrinology Glucagon-Like Peptide 1 Weight loss Orexigenic Internal medicine Humans Medicine Peptide YY Single-Blind Method Resting energy expenditure Obesity education Meals media_common Meal education.field_of_study 030109 nutrition & dietetics Nutrition and Dietetics Plant Extracts business.industry digestive oral and skin physiology Calorimetry Indirect Postprandial Period Ghrelin Female Basal Metabolism Capsaicin medicine.symptom Capsicum Energy Intake business medicine.drug |
| Zdroj: | Nutrition Research. 52:71-79 |
| ISSN: | 0271-5317 |
| DOI: | 10.1016/j.nutres.2018.02.002 |
| Popis: | Although capsaicin has been reported to reduce energy intake and increase energy expenditure in an adult (normal weight or overweight) population, thus resulting in a net negative energy balance and weight loss, these beneficial effects have not been investigated in young obese subjects. We hypothesize that capsaicin acutely administered in young obese subjects exerts the same effects on energy balance and that these effects are mediated by changes in gastrointestinal peptides regulating appetite. Thus, the aim of the present study was to evaluate the acute effects of capsaicin (2 mg) or placebo on energy intake, hunger, and satiety in obese adolescents and young adults (female-male ratio: 4:6, age: 21.0 ± 5.8 years; body mass index: 41.5 ± 4.3 kg/m2) provided an ad libitum dinner. Furthermore, circulating levels of some orexigenic (ghrelin) and anorexigenic (glucagon-like peptide 1 and peptide YY) peptides were measured after a meal completely consumed (lunch), together with the evaluation of hunger and satiety and assessment of resting energy expenditure (REE) through indirect computerized calorimetry. When compared to placebo, capsaicin did not significantly change either energy intake or hunger/satiety 6 hours after its administration (dinner). No differences in circulating levels of ghrelin, glucagon-like peptide 1, and peptide YY and in hunger/satiety were found in the 3 hours immediately after food ingestion among obese subjects treated with capsaicin or placebo (lunch). By contrast, the meal significantly increased REE in the capsaicin- but not placebo-treated group (capsaicin: from 1957.2 ± 455.1 kcal/d up to 2342.3 ± 562.1 kcal/d, P < .05; placebo: from 2060.1 ± 483.4 kcal/d up to 2296.0 ± 484.5 kcal/d). The pre-post meal difference in REE after capsaicin administration was significantly higher than that observed after placebo (385.1 ± 164.4 kcal/d vs 235.9 ± 166.1 kcal/d, P < .05). In conclusion, although capsaicin does not exert hypophagic effects, these preliminary data demonstrate its ability as a metabolic activator in young obese subjects. |
| Databáze: | OpenAIRE |
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