The effect of L-carnitine on oxidative stress responses of experimental contrast-induced nephropathy in rats
| Autor: | Cavit Kum, Osman Alper Onbasili, Çağdaş Akgüllü, Hulya Turgut, Ufuk Eryılmaz, Murat Boyacioglu |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Contrast-induced nephropathy Contrast Media Spleen Biology medicine.disease_cause Nephropathy chemistry.chemical_compound Random Allocation Laboratory Animal Science Internal medicine Carnitine Malondialdehyde medicine L-carnitine Animals Rats Wistar Kidney Creatinine antioxidant defense General Veterinary Full Paper Histocytochemistry Superoxide Dismutase medicine.disease Catalase Glutathione Rats Oxidative Stress medicine.anatomical_structure Endocrinology chemistry contrast-induced nephropathy Immunology Kidney Diseases Oxidative stress medicine.drug |
| Zdroj: | The Journal of Veterinary Medical Science |
| ISSN: | 1347-7439 |
| Popis: | This study was conducted to investigate the prophylactic effects of carnitine against contrast-induced nephropathy (CIN) and its relation to oxidant/antioxidant status in kidney, liver, heart, spleen and lung tissues in a CIN rat model. Twenty-eight adult male Wistar rats were divided into 4 groups, the control, contrast media (CM), carnitine and contrast media+carnitine (CM+carnitine) groups. Animals were placed in individual metabolism cages, and on the 2nd day, rats were deprived of water for 24 hr. On the 3rd day, contrast media were administered to groups CM and CM+carnitine. L-carnitine was administered on days 2, 3 and 4. Histopathological changes were evaluated in the right kidney after euthanization. Superoxide dismutase (SOD) and catalase (CAT) activities and glutathione (GSH) and malondialdehyde (MDA) levels were measured in renal, liver, heart, spleen and lung tissues. The SOD activities in the renal (P |
| Databáze: | OpenAIRE |
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