Scalable, efficient and rapid chemical synthesis of l-Fructose with high purity

Autor:	Liyu Zhao, Tianxiao Wu, Yang Liu, Xinjing Song, Maosheng Cheng, Dongmei Zhao, Qiaohua Qin, Jihui Li
Rok vydání:	2019
Předmět:	Models Molecular Chromatography Organic Chemistry Stereoisomerism Fructose Chemistry Techniques Synthetic General Medicine Sorbose Biochemistry Chemical synthesis Analytical Chemistry Kinetics chemistry.chemical_compound chemistry Yield (chemistry) Carbohydrate Conformation
Zdroj:	Carbohydrate Research. 480:67-72
ISSN:	0008-6215
DOI:	10.1016/j.carres.2019.05.010
Popis:	An improved process for chemical synthesis of l -fructose with high purity in large scale from readily available l -sorbose is described. In general, this synthetic scheme is characterized by inexpensive and easily available starting materials, simple and safe experimental procedures, short time period, low environmental impact, and great potential for scaling up. The scale-up experiment (100 g) was carried out to provide 42.7 g of l -fructose with high HPLC purity of 99.65% in total yield of 50.2%. Consequently, the described improvements would be helpful for those who may wish to use l -fructose and promoting the further evaluation of applications of l -fructose.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8cb526dbd370d26369e5e86ae7af0b4 https://doi.org/10.1016/j.carres.2019.05.010 Zobrazit plný text záznamu Full Text from ScienceDirect