Anxiolytic-like effect of trans-2-decenoic acid ethyl ester in stress-induced anxiety-like model mice
| Autor: | Hidefumi Fukumitsu, Hitomi Soumiya, Yoshiko Furukawa, Akihisa Makino, Munekazu Iinuma, Shoei Furukawa |
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| Rok vydání: | 2013 |
| Předmět: |
Male
MAPK/ERK pathway medicine.drug_class Anxiety Pharmacology Hippocampus Anxiolytic General Biochemistry Genetics and Molecular Biology Fatty Acids Monounsaturated Mice Stress Physiological Neurotrophic factors medicine Extracellular Animals Hippocampus (mythology) Nerve Growth Factors RNA Messenger Phosphorylation Mitogen-Activated Protein Kinase 1 Mitogen-Activated Protein Kinase 3 Chemistry Kinase General Medicine medicine.disease Disease Models Animal Gene Expression Regulation Mood disorders Mechanism of action medicine.symptom Stress Psychological |
| Zdroj: | Biomedical Research. 34:259-267 |
| ISSN: | 1880-313X 0388-6107 |
| Popis: | Brain-derived neurotrophic factor (BDNF) is considered to be involved in the etiology and treatment of stress-related mood disorders including anxiety. However, application of BDNF itself has many technical and pharmacological problems such as instability and/or a lack of appropriate delivery systems. To overcome these, we developed trans-2-decenoic acid ethyl ester (DAEE) as a stable and small molecule with BDNF-like activities. In the present study, we tested the activities of DAEE on a stress-induced anxiety-like mouse model. Mice were kept in cages and subjected to 3 sets of sequential leaning, drenching, and rotation as chronic mild stresses applied for 1-2 days over a 3-week period; and the anxiety-like symptom (reduced time spent in open arm of the maze) was evaluated by use of the elevated plus-maze test. A daily intraperitoneal administration of DAEE competed against the expression of the anxiety-like symptom when administered during the stress-loading period, and became therapeutic when administered after the stress-loading. This activity was accompanied by amelioration of the stress-induced reduction in the levels of BDNF and neurotrophin-3 mRNAs and phosphorylated extracellular signal-regulated kinases (ERK) 1/2 in the hippocampus. These results demonstrated that DAEE behaved like an anxiolytic and ameliorated this characteristic anxiety-like symptom, suggesting that DAEE may be a promising candidate for a novel anxiolytic with a new mechanism of action. |
| Databáze: | OpenAIRE |
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