CD94/NKG2A Expression Is Associated with Proliferative Potential of CD8 T Cells during Persistent Polyoma Virus Infection
| Autor: | Nicolas P. Andrews, Anthony M. Byers, Aron E. Lukacher |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
viruses
Immunology Epitopes T-Lymphocyte CD8-Positive T-Lymphocytes Biology Lymphocyte Activation Virus Mice Interleukin 21 Immunity Animals Immunology and Allergy Cytotoxic T cell IL-2 receptor Receptors Immunologic Cells Cultured Cell Proliferation Mice Inbred C3H Polyomavirus Infections Cell Cycle Cell cycle Virology Tumor Virus Infections Viral replication Receptors Natural Killer Cell Female NK Cell Lectin-Like Receptor Subfamily C Polyomavirus NK Cell Lectin-Like Receptor Subfamily D Ex vivo |
| Zdroj: | The Journal of Immunology. 176:6121-6129 |
| ISSN: | 1550-6606 0022-1767 |
| Popis: | Memory CD8 T cells comprise a critical component of durable immunity because of their capacity to rapidly proliferate and exert effector activity upon Ag rechallenge. During persistent viral infection, memory CD8 T cells repetitively encounter viral Ag and must maintain a delicate balance between limiting viral replication and minimizing immunopathology. In mice infected by polyoma virus, a natural mouse pathogen that establishes long-term persistent infection, the majority of persistence-phase antiviral CD8 T cells express the inhibitory NK cell receptor CD94/NKG2A. In this study, we asked whether CD94/NKG2A expression is associated with Ag-specific recall of polyoma virus-specific CD8 T cells. During the persistent phase of infection, polyoma virus-specific CD8 T cells that express CD94/NKG2A were found to preferentially proliferate; this proliferation was dependent on cognate Ag both in vitro and in vivo. In addition, CD94/NKG2A+ polyoma-specific CD8 T cells have a markedly enhanced capacity to produce IL-2 upon ex vivo Ag stimulation compared with CD94/NKG2A− polyoma-specific CD8 T cells. Importantly, CD94/NKG2A+ anti-polyoma virus CD8 T cells appear to be essential for Ag-specific recall responses in mice persistently infected by polyoma virus. Because of its higher proliferative potential and capacity to produce IL-2, we propose that the CD94/NKG2A+ subpopulation represents a less differentiated state than the CD94/NKG2A− subpopulation. Identification of proliferation-competent subpopulations of memory CD8 T cells should prove valuable in designing therapeutic vaccination strategies for persistent viral infections. |
| Databáze: | OpenAIRE |
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