Identification and Structure Elucidation of Epoxyjanthitrems from Lolium perenne Infected with the Endophytic Fungus Epichloë festucae var. lolii and Determination of the Tremorgenic and Anti-Insect Activity of Epoxyjanthitrem I

Autor: Michèle R. Prinsep, Sarah C. Finch, Alison J. Popay, Alistair L. Wilkins, Nicola G. Webb, B. A. Tapper, Joanne G. Jensen, JV Babu, Allan D. Hawkes, Geoffrey A. Lane, Sweta Bhattarai
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Toxins, Vol 12, Iss 526, p 526 (2020)
Toxins
Volume 12
Issue 8
ISSN: 2072-6651
Popis: Epoxyjanthitrems I&ndash
IV (1&ndash
4) and epoxyjanthitriol (5) were isolated from seed of perennial ryegrass (Lolium perenne) infected with the endophytic fungus Epichloë
festucae var. lolii. Although structures for epoxyjanthitrems I&ndash
IV have previously been proposed in the literature, this is the first report of a full structural elucidation yielding NMR (Nuclear magnetic resonance) assignments for all five epoxyjanthitrem compounds, and additionally, it is the first isolation of epoxyjanthitriol (5). Epoxyjanthitrem I induced tremors in mice and gave a dose dependent reduction in weight gain and feeding for porina (Wiseana cervinata), a common pasture pest in New Zealand. These data suggest that epoxyjanthitrems are involved in the observed effects of the AR37 endophyte on livestock and insect pests.
Databáze: OpenAIRE