Identification and Structure Elucidation of Epoxyjanthitrems from Lolium perenne Infected with the Endophytic Fungus Epichloë festucae var. lolii and Determination of the Tremorgenic and Anti-Insect Activity of Epoxyjanthitrem I
Autor: | Michèle R. Prinsep, Sarah C. Finch, Alison J. Popay, Alistair L. Wilkins, Nicola G. Webb, B. A. Tapper, Joanne G. Jensen, JV Babu, Allan D. Hawkes, Geoffrey A. Lane, Sweta Bhattarai |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Perennial plant
040301 veterinary sciences Health Toxicology and Mutagenesis media_common.quotation_subject lcsh:Medicine Insect Toxicology Pasture Porina Endophyte Lolium perenne 0403 veterinary science 03 medical and health sciences Botany tremorgen 030304 developmental biology media_common 0303 health sciences geography geography.geographical_feature_category Epichloë festucae var. lolii biology lcsh:R 04 agricultural and veterinary sciences Endophytic fungus biology.organism_classification AR37 porina epoxyjanthitrem PEST analysis ryegrass staggers endophyte |
Zdroj: | Toxins, Vol 12, Iss 526, p 526 (2020) Toxins Volume 12 Issue 8 |
ISSN: | 2072-6651 |
Popis: | Epoxyjanthitrems I&ndash IV (1&ndash 4) and epoxyjanthitriol (5) were isolated from seed of perennial ryegrass (Lolium perenne) infected with the endophytic fungus Epichloë festucae var. lolii. Although structures for epoxyjanthitrems I&ndash IV have previously been proposed in the literature, this is the first report of a full structural elucidation yielding NMR (Nuclear magnetic resonance) assignments for all five epoxyjanthitrem compounds, and additionally, it is the first isolation of epoxyjanthitriol (5). Epoxyjanthitrem I induced tremors in mice and gave a dose dependent reduction in weight gain and feeding for porina (Wiseana cervinata), a common pasture pest in New Zealand. These data suggest that epoxyjanthitrems are involved in the observed effects of the AR37 endophyte on livestock and insect pests. |
Databáze: | OpenAIRE |
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