Expression of the albumin gene in rat hepatoma cells and their dedifferentiated variants
| Autor: | MariaOdile Ott, Jeanne Fries, Tamas Erdos, Mary C. Weiss, Doris Cassio, José M. Sala-Trepat |
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| Rok vydání: | 1981 |
| Předmět: |
Transcription
Genetic Somatic cell Cellular differentiation Cell Biology Hybrid Cells General Biochemistry Genetics and Molecular Biology Liver Neoplasms Experimental Albumins medicine Animals RNA Messenger Gene Regulation of gene expression Messenger RNA Albumin Nucleic Acid Hybridization Cell Differentiation DNA Molecular biology Clone Cells Rats Somatic fusion Kinetics medicine.anatomical_structure Gene Expression Regulation |
| Zdroj: | Cell. 27(2 Pt 1) |
| ISSN: | 0092-8674 |
| Popis: | Rat hepatoma clones whose cells do and do not produce albumin, as well as somatic hybrid between the two types of cells, have been examined for albumin mRNA. A direct proportionality between the rate of albumin production and the concentration of albumin mRNA sequences was found for all albumin-producing hepatoma and hybrid clones, indicating that rate of synthesis of the protein is determined by the concentration of its mRNA. Albumin-negative dedifferentiated variant and somatic hybrid cells contain fewer than one to five molecules of albumin mRNA per cell; the block in expression of the gene appears to be at the same (probably transcriptional) level in variants and their somatic hybrids. |
| Databáze: | OpenAIRE |
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