Fibroblast Growth Factor 2 and Its Receptors in Bone Biology and Disease
| Autor: | Collin Homer-Bouthiette, J. Douglas Coffin, Marja M. Hurley |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Osteomalacia Mini-Reviews biology FGF2 Cell growth Endocrinology Diabetes and Metabolism Cartilage Morphogenesis medicine.disease Fibroblast growth factor bone Receptor tyrosine kinase Cell biology Growth Growth Hormone and Growth Factors 03 medical and health sciences FGF receptors 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure 030220 oncology & carcinogenesis biology.protein medicine Signal transduction Receptor |
| Zdroj: | Journal of the Endocrine Society |
| ISSN: | 2472-1972 |
| Popis: | The fibroblast growth factor (FGF) regulatory axis is phylogenetically ancient, evolving into a large mammalian/human gene family of 22 ligands that bind to four receptor tyrosine kinases for a complex physiologic system controlling cell growth, differentiation, and metabolism. The tissue targets for the primary FGF function are mainly in cartilage and in bone for morphogenesis, mineralization, and metabolism. A multitude of complexities in the FGF ligand-receptor signaling pathways have made translation into therapies for FGF-related bone disorders such as osteomalacia, osteoarthritis, and osteoporosis difficult but not impossible. The article reviews the role of FGF2 and its receptors in bone biology and disease, focusing on our current understanding, gaps in knowledge, and future studies that are needed. |
| Databáze: | OpenAIRE |
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