Tocotrienols reach the brain and play roles in the attenuation of body weight gain and improvement of cognitive function in high-fat diet-treated mice
| Autor: | Hirokatsu Takatsu, Yoshinori Aoki, Hayami Uchiumi, Shogo Endo, Yugo Kato, Shuichi Yanai, Koji Fukui, Ryo Usami |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Antioxidant medicine.medical_treatment Clinical Biochemistry Medicine (miscellaneous) blood brain barrier vitamin E Type 2 diabetes Blood–brain barrier Internal medicine Lipid droplet anti-obesity effects medicine fatty liver Nutrition and Dietetics business.industry Vitamin E Fatty liver Cognition medicine.disease Obesity medicine.anatomical_structure Endocrinology Original Article antioxidative defense systems business |
| Zdroj: | Journal of Clinical Biochemistry and Nutrition |
| ISSN: | 1880-5086 0912-0009 |
| DOI: | 10.3164/jcbn.21-10 |
| Popis: | Obesity induces severe disorders such as type 2 diabetes and cardiovascular events, and the number of people with obesity is increasing all over the world. Furthermore, it is possible that obesity increases the risk of cognitive dysfunction via the acceleration of oxidative damage. Tocotrienols, which are part of the vitamin E family, have antioxidant and anti-obesity effects. However, the effects of tocotrienols on high-fat diet-treated mice have not been completely elucidated. In this study, we assessed changes in body weight, spatial reference memory acquisition, liver lipid droplet size, blood brain barrier-related protein expressions and antioxidative defense systems in high-fat diet-treated mice in the presence or absence of tocotrienols. The results showed that tocotrienols significantly inhibited body weight gain and lipid droplet synthesis. Although the amount was very small, it was confirmed that tocotrienols surely reached the brain in the perfused brain. Treatment with tocotrienols was tended to improve cognitive function in the control mice. However, tocotrienols did not modulate blood brain barrier-related protein expressions or antioxidative defense systems. These results indicate that treatment with tocotrienols could be effective for the prevention of obesity and cognitive dysfunction. Further extended research is needed to elucidate the relationship between anti-obesity and antioxidant effects of tocotrienols, especially in the brain. |
| Databáze: | OpenAIRE |
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