Receptor activities of persistent pollutant serum mixtures and breast cancer risk
| Autor: | Maria Wielsøe, Eva Cecilie Bonefeld-Jørgensen, Christian Bjerregaard-Olesen, Peder Kern |
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| Rok vydání: | 2018 |
| Předmět: |
Risk
Cancer Research medicine.medical_specialty Endocrinology Diabetes and Metabolism organochlorine pesticides (OCPs) Greenland Estrogen receptor Breast Neoplasms polychlorinated biphenyl (PCB) Endocrine Disruptors 010501 environmental sciences 01 natural sciences xenohormone and dixon-like receptor activity Cell Line 03 medical and health sciences Cricetulus 0302 clinical medicine Endocrinology Breast cancer Internal medicine Journal Article arctic Animals Humans Medicine perfluoroalkyl acid (PFAA) Receptor 0105 earth and related environmental sciences Pollutant biology business.industry Estrogens Cellular receptor medicine.disease Aryl hydrocarbon receptor Androgen receptor Receptors Aryl Hydrocarbon Receptors Estrogen Oncology Inuit Receptors Androgen 030220 oncology & carcinogenesis biology.protein Environmental Pollutants Female business Hormone |
| Zdroj: | Wielsøe, M, Bjerregaard-Olesen, C, Kern, P & Bonefeld-Jørgensen, E C 2018, ' Receptor activities of persistent pollutant serum mixtures and breast cancer risk ', Endocrine-Related Cancer, vol. 25, no. 3, pp. 201-215 . https://doi.org/10.1530/ERC-17-0366 |
| ISSN: | 1479-6821 1351-0088 |
| DOI: | 10.1530/erc-17-0366 |
| Popis: | Studies on associations between persistent organic pollutants (POPs) and breast cancer risk are inconclusive. The majority of studies have evaluated the effect of single compounds, without considering multiple exposures to and interactions between different POPs. The present study aimed at evaluating breast cancer risk related to combined effects of serum POP mixtures on cellular receptor functions. Data on breast cancer cases (n = 77) and controls (n = 84) were collected among Greenlandic Inuit women. Serum mixtures of lipophilic POPs (lipPOPs), perfluoroalkyl acids (PFAAs) and dioxin-like POPs were extracted. The effect of the mixture extracts on the estrogen receptor (ER), androgen receptor (AR) and aryl hydrocarbon receptor (AhR) was determined using cell culture reporter gene assays. The serum mixtures were analyzed alone and upon co-exposure with natural receptor ligands to determine agonistic and antagonistic/competitive activity. We found that the frequency of lipPOP mixtures eliciting no, decreasing, or agonizing xenoandrogenic effect differed by breast cancer status. Using lipPOP mixtures with no effect on AR as reference, the mixtures with decreasing effects reduced breast cancer risk (OR: 0.30 (0.12; 0.76)). The AhR-toxic equivalent of serum mixtures was significantly lower in cases than in controls, and a reduced breast cancer risk was found when comparing the third tertile to the first (OR: 0.34 (0.14; 0.83)). We found no association between the xenoestrogenic activities of lipPOPs or PFAAs and breast cancer risk. Serum lipPOP mixtures are hormone disruptive and may influence breast cancer risk, whereas PFAAs seem to influence breast cancer risk through other pathways. |
| Databáze: | OpenAIRE |
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