Differential effects of social isolation in adolescent and adult mice on behavior and cortical gene expression
| Autor: | Donna Linder-Shacham, Sharon S Lander, Inna Gaisler-Salomon |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male Aging Dextroamphetamine Psychotomimetic drug Prefrontal Cortex Inhibitory postsynaptic potential Avian Proteins 03 medical and health sciences Behavioral Neuroscience Mice 0302 clinical medicine Glutaminase medicine Animals RNA Messenger Prefrontal cortex Amphetamine Maze Learning Social Behavior Glutamate receptor Recognition Psychology Excitatory Amino Acid Transporter 1 030104 developmental biology Anxiogenic Gene Expression Regulation Social Isolation Vesicular Glutamate Transport Protein 1 Excitatory postsynaptic potential Central Nervous System Stimulants Psychology Neuroscience 030217 neurology & neurosurgery Developmental psychopathology Locomotion medicine.drug Transcription Factors |
| Zdroj: | Behavioural brain research. 316 |
| ISSN: | 1872-7549 |
| Popis: | Intact function of the medial prefrontal cortex (mPFC) function relies on proper development of excitatory and inhibitory neuronal populations and on integral myelination processes. Social isolation (SI) affects behavior and brain circuitry in adulthood, but previous rodent studies typically induced prolonged (post-weaning) exposure and failed to directly compare between the effects of SI in adolescent and adulthood. Here, we assessed the impact of a 3-week SI period, starting in mid-adolescence (around the onset of puberty) or adulthood, on a wide range of behaviors in adult male mice. Additionally, we asked whether adolescent SI would differentially affect the expression of excitatory and inhibitory neuronal markers and myelin-related genes in mPFC. Our findings indicate that mid-adolescent or adult SI increase anxiogenic behavior and locomotor activity. However, SI in adolescence uniquely affects the response to the psychotomimetic drug amphetamine, social and novelty exploration and performance in reversal and attentional set shifting tasks. Furthermore, adolescent but not adult SI increased the expression of glutamate markers in the adult mPFC. Our results imply that adolescent social deprivation is detrimental for normal development and may be particularly relevant to the investigation of developmental psychopathology. |
| Databáze: | OpenAIRE |
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