Involvement of transcribed lncRNA uc.291 and SWI/SNF complex in cutaneous squamous cell carcinoma
| Autor: | Mancini, M., Cappello, A., Pecorari, R., Lena, A. M., Montanaro, M., Fania, L., Ricci, F., Di Lella, G., Piro, M. C., Abeni, D., Dellambra, E., Mauriello, A., Melino, G., Candi, E. |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Cancer Research Endocrinology Diabetes and Metabolism Settore MED/08 Biology medicine.disease_cause 03 medical and health sciences 0302 clinical medicine Endocrinology Squamous cell carcinoma medicine Settore BIO/10 Gene Messenger RNA SWI/SNF complex Endocrine and Autonomic Systems Settore BIO/11 Research Molecular medicine LncRNA Chromatin 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Basal cell carcinoma Cancer research ACTL6A Regulatory Pathway Epidermis Keratinocyte Carcinogenesis |
| Zdroj: | Discover. Oncology |
| Popis: | While non-melanoma skin cancers (NMSCs) are the most common tumours in humans, only the sub-type cutaneous squamous cell carcinoma (cSCC), might become metastatic with high lethality. We have recently identified a regulatory pathway involving the lncRNA transcript uc.291 in controlling the expression of epidermal differentiation complex genes via the interaction with ACTL6A, a component of the chromatin remodelling complex SWI/SNF. Since transcribed ultra-conserved regions (T-UCRs) are expressed in normal tissues and are deregulated in tumorigenesis, here we hypothesize a potential role for dysregulation of this axis in cSCC, accounting for the de-differentiation process observed in aggressive poorly differentiated cutaneous carcinomas. We therefore analysed their expression patterns in human tumour biopsies at mRNA and protein levels. The results suggest that by altering chromatin accessibility of the epidermal differentiation complex genes, down-regulation of uc.291 and BRG1 expression contribute to the de-differentiation process seen in keratinocyte malignancy. This provides future direction for the identification of clinical biomarkers in cutaneous SCC. Analysis of publicly available data sets indicates that the above may also be a general feature for SCCs of different origins. Supplementary Information The online version contains supplementary material available at 10.1007/s12672-021-00409-6. |
| Databáze: | OpenAIRE |
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