Cardiovascular risk and mortality in end-stage renal disease patients undergoing dialysis: sleep study, pulmonary function, respiratory mechanics, upper airway collapsibility, autonomic nervous activity, depression, anxiety, stress and quality of life: a prospective, double blind, randomized controlled clinical trial

Autor: Israel Reis Santos, Luis Vicente Franco de Oliveira, Sergio Roberto Nacif, Lilian C Giannasi, Daniel Giannella-Neto, Ezequiel Fernandes Oliveira, Salvatore Romano, Paulo de Tarso Camillo de Carvalho, Leonardo Macario Ferraz, Isabella de Carvalho Aguiar, Aline Roberta Danaga, Giuseppe Insalaco, Viviane Cristina Delgado Lopes, Luciana Maria Malosá Sampaio, Humberto Dellê, Ismael Souza Dias, Nina Teixeira Fonsêca, Vinicius Alves Thomaz Fernandes, Ana Karina Fachini Araujo, Virgilio Fernandes, Nadia Karina Guimaraees Souza, Aline Almeida Martins, Fernando Sergio Studart Leitão Filho, Jessica Julioti Urbano
Přispěvatelé: Universidade Nove de Julho (UNINOVE), Universidade Estadual de Ciências da Saúde de Alagoas (UNCISAL), Ctr Nefrol Zona Norte CENENORTE, Fortaleza Univ UNIFOR, Universidade Estadual Paulista (Unesp), CNR
Rok vydání: 2013
Předmět:
Zdroj: BMC Nephrology
Web of Science
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
ISSN: 1471-2369
Popis: Made available in DSpace on 2014-12-03T13:08:44Z (GMT). No. of bitstreams: 0 Previous issue date: 2013-10-08Bitstream added on 2014-12-03T13:23:39Z : No. of bitstreams: 1 WOS000327480700002.pdf: 737624 bytes, checksum: 82c53e2a7c003806c43197f5f5a53ae1 (MD5) Nove de Julho University (Brazil) Background: Chronic kidney disease (CKD) is one of the most serious public health problems. The increasing prevalence of CKD in developed and developing countries has led to a global epidemic. The hypothesis proposed is that patients undergoing dialysis would experience a marked negative influence on physiological variables of sleep and autonomic nervous system activity, compromising quality of life.Methods/Design: A prospective, consecutive, double blind, randomized controlled clinical trial is proposed to address the effect of dialysis on sleep, pulmonary function, respiratory mechanics, upper airway collapsibility, autonomic nervous activity, depression, anxiety, stress and quality of life in patients with CKD. The measurement protocol will include body weight (kg); height (cm); body mass index calculated as weight/height(2); circumferences (cm) of the neck, waist, and hip; heart and respiratory rates; blood pressures; Mallampati index; tonsil index; heart rate variability; maximum ventilatory pressures; negative expiratory pressure test, and polysomnography (sleep study), as well as the administration of specific questionnaires addressing sleep apnea, excessive daytime sleepiness, depression, anxiety, stress, and quality of life.Discussion: CKD is a major public health problem worldwide, and its incidence has increased in part by the increased life expectancy and increasing number of cases of diabetes mellitus and hypertension. Sleep disorders are common in patients with renal insufficiency. Our hypothesis is that the weather weight gain due to volume overload observed during interdialytic period will influence the degree of collapsibility of the upper airway due to narrowing and predispose to upper airway occlusion during sleep, and to investigate the negative influences of haemodialysis in the physiological variables of sleep, and autonomic nervous system, and respiratory mechanics and thereby compromise the quality of life of patients. Nove de Julho Univ UNINOVE, Rehabil Sci Master Degree & PhD Program, Sao Paulo, Brazil Nove de Julho Univ UNINOVE, Phys Therapy Sch, Sao Paulo, Brazil Nove de Julho Univ UNINOVE, Psychol Sch, Dept Hlth, Sao Paulo, Brazil Univ Estadual Ciencias Saude Alagoas UNCISAL, Phys Therapy Sch, Maceio, AL, Brazil Ctr Nefrol Zona Norte CENENORTE, Sao Paulo, Brazil Fortaleza Univ UNIFOR, Med Sch, Fortaleza, Ceara, Brazil Univ Estadual Paulista UNESP SJC, Biosci Dept, Sao Paulo, Brazil CNR, Ist Biomed & Immunol Mol Alberto Monroy IBIM, Palermo, SI, Italy Nove de Julho Univ UNINOVE, Med Master Degree Program, Sao Paulo, Brazil Nove de Julho Univ UNINOVE, Sleep Lab, Sao Paulo, Brazil Univ Estadual Paulista UNESP SJC, Biosci Dept, Sao Paulo, Brazil
Databáze: OpenAIRE
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