A1166C polymorphism of angiotensin II type 1 receptor, blood pressure and arterial stiffness in hypertension
| Autor: | Giampiero Bricca, Madeleine Vincent, Stéphany Gardier, Pierre Lantelme, M. O. Rial, Hugues Milon |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Angiotensin receptor medicine.medical_specialty Adolescent Genotype Physiology Posture Population Blood Pressure Receptor Angiotensin Type 1 Polymorphism (computer science) Internal medicine Internal Medicine medicine Humans education Aldosterone Pulse wave velocity Alleles Aged education.field_of_study Polymorphism Genetic business.industry Middle Aged medicine.disease Angiotensin II Blood pressure Mean blood pressure Endocrinology Hypertension Cardiology Arterial stiffness Female Cardiology and Cardiovascular Medicine business Blood Flow Velocity |
| Zdroj: | Journal of Hypertension. 22:2135-2142 |
| ISSN: | 0263-6352 |
| DOI: | 10.1097/00004872-200411000-00016 |
| Popis: | Objective To study the association of the A 1166 C polymorphism of angiotensin II type 1 receptor gene (AGTR1) with blood pressure and central arterial stiffness in a population of hypertensive patients referred to hospital for further work-up. Methods One hundred and eighty-five patients, referred to our department from April 1998 to February 2002, were included. Blood pressure was measured by conventional and 24-h ambulatory methods, and arterial stiffness by carotid-femoral pulse wave velocity (PWV) determination. Genotyping for the AGTR1 A 1166 C polymorphism was performed by polymerase chain reaction. Results AGTR1 A 1166 C polymorphism was not associated with systolic or diastolic blood pressure, measured either by conventional (P = 0.89 and P = 0.67, respectively) or by 24-h ambulatory (P = 0.57 and P = 0.56, respectively) methods. Conversely, this polymorphism was significantly associated with PWV (P= 0.006) and had a dose-allele effect, PWV increasing with the number of A alleles (10.6 ± 2A m/s in CC, 11.9 ± 2.5 m/s in AC and 12.7 ± 2.7 m/s in AA patients, P= 0.002). Multiple regression analysis showed that A 1166 C polymorphism was still independently associated with PWV (P = 0.01) and was the third most important determinant of PWV after age (P< 0.0001) and 24-h mean blood pressure (P < 0.0001). Conclusion In our study population, central arterial stiffness assessed by PWV was significantly and independently associated with the A 1166 C polymorphism, increased PWV being associated with the presence of the A allele. Further investigations are required for identification of the underlying mechanisms. |
| Databáze: | OpenAIRE |
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