Cognitive disorders in the elderly. Genetic and epigenetic aspects

Autor:	Maurizio Sampietro, A. Casatta, Giorgio Annoni, Jacopo Tagliabue, A. Pellegatti, Ludovica Caputo, Carlo Vergani, M. Meregalli
Přispěvatelé:	Vergani, C, Sampietro, M, Caputo, L, Tagliabue, J, Casatta, A, Meregalli, M, Pellegatti, A, Annoni, G
Rok vydání:	2001
Předmět:	Apolipoprotein E Genetics Aging Health (social science) business.industry Hfe gene Cognition hemochromatosi Alzheimer's disease medicine.disease Medicine iron metabolism Epigenetics MED/09 - MEDICINA INTERNA Geriatrics and Gerontology HFE gene business Gerontology Hemochromatosis ApoE
Zdroj:	Archives of Gerontology and Geriatrics. 33:429-434
ISSN:	0167-4943
DOI:	10.1016/s0167-4943(01)00170-4
Popis:	Alzheimer's disease (AD) represents the most prevalent manifestation of the cognitive disorders in the elderly. The dramatic nature and the economic burden of the disease make AD a worl-wide problem. This paper reviews the genetic factors which explain the pathogenesis of AD, i.e., mutations of the genes encoding the amyloid precursor protein (APP), presenilin 1 (PS-1) and 2 (PS-2). Moreover, the polymorphism of the ApoE gene and the mutations of the hemochromatosis gene (HFE) are discussed. HFE mutations may anticipate the clinical manifestation of AD. The epigenetic factors related to AD are also discussed
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8bd835daa1f395903bee3e71f52f1c7 https://doi.org/10.1016/s0167-4943(01)00170-4 Zobrazit plný text záznamu Full Text from ScienceDirect