Immunologic hurdles of therapeutic stem cell transplantation
| Autor: | Zeinab Abdullah, Martin Krönke, Udo Siebolts, Claudia Wickenhauser, Afra Engelmann, Nikola Baschuk, Carol Stocking, Olaf Utermöhlen |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
T-Lymphocytes Clinical Biochemistry Cell Embryo Biology Regenerative Medicine Biochemistry Embryonic stem cell Regenerative medicine Cell biology Transplantation Killer Cells Natural Adult Stem Cells medicine.anatomical_structure medicine Cytotoxic T cell Animals Humans Stem cell Molecular Biology Embryonic Stem Cells Adult stem cell Stem Cell Transplantation |
| Zdroj: | Biological chemistry. 390(10) |
| ISSN: | 1437-4315 |
| Popis: | Detailed knowledge of the immunologic properties of embryonic stem (ES) cells is a prerequisite for safe applications of ES cell-based regenerative medicine. Recently, the long-standing assumption that ES cells are ignored by immunocompetent hosts was disproved. Instead, it is becoming increasingly clear that ES cells actively protect themselves via several immunomodulatory and immunoevasive mechanisms against cytotoxic T-lymphocytes and natural killer cells. Here we review current knowledge about the immunologic properties of ES cells and discuss the implications for ES cell-based regenerative medicine, for the immunobiology of the embryo as a semi-allogeneic graft, and for the regenerative capacity of adult stem cells. |
| Databáze: | OpenAIRE |
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