An immunohistochemical study on cutaneous sensory receptors after chronic median nerve compression in man
| Autor: | Giancarlo Panzica, G. Cellino, Maurizio Stella, Guglielmo Ramieri, Maurizio Calcagni |
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| Přispěvatelé: | University of Zurich, Ramieri, G |
| Předmět: |
Male
Histology Sensory Receptor Cells Nerve root Calcitonin Gene-Related Peptide Nerve Tissue Proteins Sensory system 610 Medicine & health Calcitonin gene-related peptide 2722 Histology Nerve conduction velocity Nerve Fibers Humans Medicine Neuropeptide Y Receptor Carpal tunnel syndrome 10266 Clinic for Reconstructive Surgery Skin business.industry S100 Proteins Sensory loss Anatomy medicine.disease 2702 Anatomy Carpal Tunnel Syndrome Immunohistochemistry Peptide Fragments Electrophysiology Female Thiolester Hydrolases business Ubiquitin Thiolesterase |
| Zdroj: | Scopus-Elsevier Europe PubMed Central |
| Popis: | Carpal tunnel syndrome represents the most frequent chronic compressive neuropathy in man and hence may be investigated as a spontaneous model of peripheral nerve damage and repair. In the present report the fate of nerve fibers in the digital skin after long-lasting median nerve compression has been investigated immunohistochemically in comparison to normal digital skin, with special consideration to sensory endings and encapsulated receptors. The presence has been documented of the neurospecific marker PGP 9.5, the glia-associated protein S-100, and the neuropeptides CGRP and CPON which are mainly associated with the sensory and sympathetic nerve fibers respectively. The morphology and distribution of nerve fibers and corpuscles appeared comparable to that of normal digital skin; a reduction in the density of sensory receptors has, however, been observed, although not to the degree that was expected to explain the clinical deficits. It has been also demonstrated that at least part of the CGRP-containing sensory and CPON-containing sympathetic axons may survive unaltered even in patients with a long clinical history of profound sensorial impairment. An apparent discrepancy between the maintenance of nerve fibers and the sensory disturbances and the frequent observation of prompt postoperative recovery even after years of compression results from this investigation. The correlation of immunohistochemical observations and functional scores may not be considered conclusive. It must, however, be discussed if the sensorial impairment in this syndrome might have, at least in some cases, not only an anatomical but also an electrophysiological basis. |
| Databáze: | OpenAIRE |
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