Alternaria as a major allergen for asthma in children raised in a desert environment
| Autor: | Marilyn Halonen, L. M. Taussig, Fernando D. Martinez, Debra A. Stern, Anne L. Wright |
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| Rok vydání: | 1997 |
| Předmět: |
Pulmonary and Respiratory Medicine
Male Allergy Antigens Fungal Rhinitis Allergic Perennial Time Factors Critical Care and Intensive Care Medicine Immunoglobulin E medicine.disease_cause Allergen Sex Factors Risk Factors Immunopathology otorhinolaryngologic diseases Prevalence Medicine Humans Longitudinal Studies Prospective Studies Child Asthma Skin Tests biology business.industry Case-control study Arizona Alternaria Environmental exposure Environmental Exposure Allergens biology.organism_classification medicine.disease respiratory tract diseases Logistic Models Case-Control Studies Immunology biology.protein Female Desert Climate business |
| Zdroj: | American journal of respiratory and critical care medicine. 155(4) |
| ISSN: | 1073-449X |
| Popis: | The relationships of asthma and allergic rhinitis with individual immediate skin test responses were examined for preferential associations and for changes with age in children raised in a semiarid environment. Prevalence of physician-diagnosed asthma was 9.8% at age 6 (n = 948) and 15.5% at age 11 (n = 895). Immediate skin test responses to Bermuda grass were the most prevalent among children with allergic rhinitis and control subjects, whereas responses to the mold, Altenaria alternata, were the most prevalent among asthmatics. Skin test responses for crude house dust, Dermatophagoides farinae, and cat had low prevalences in all groups. By logistic regression, Alternaria was the only allergen independently associated with increased risk for asthma at both ages 6 and 11. Allergic rhinitis showed independent association with sensitization to Bermuda grass and mulberry tree pollen at age 11 but did not show an independent relation to any single allergen at age 6. Logistic regression further revealed that persistent asthma (diagnosed before age 6) was independently associated with Alternaria skin tests at both ages 6 and 11, whereas new asthma (diagnosed after age 6) was associated with Alternaria skin tests at age 6 but not at age 11. We conclude that Alternaria is the major allergen associated with the development of asthma in children raised in a semiarid environment and that skin test responses at age 6 are more closely linked to asthma than those at age 11. |
| Databáze: | OpenAIRE |
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