Virulence of two strains of Cowdria ruminantium in mice and their use to predict drug activity against heartwater

Autor:	N. McHardy, P. K. I. Mackenzie
Rok vydání:	1984
Předmět:	Infectivity Male Thiosemicarbazones Imidocarb animal structures Sheep Virulence Sheep Diseases Mice Inbred Strains Oxytetracycline Biology Virology Microbiology Mice Drug activity Food Animals Rickettsiaceae Animals Animal Science and Zoology Heartwater Disease
Zdroj:	Tropical animal health and production. 16(1)
ISSN:	0049-4747
Popis:	A study was made of the infectivity of two mouse-adapted strains of Cowdria ruminantium in mice. The Kwanyanga strain was most virulent in Balb/C mice which died nine days after infection with homogenate of liver from infected mice. CD-1 mice were least susceptible of six strains tested. The du Plessis strain of C. ruminantium was equally virulent in all six mouse strains. The du Plessis strain in CD-1 mice was used as the basis of a drug screen to detect activity against heartwater (C. ruminantium infection) and was highly predictive when active compounds were tested in sheep infected with the Ball 3 strain of C. ruminantium.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8b8e90ffc0e6fbf742347e94635027f https://pubmed.ncbi.nlm.nih.gov/6233776 Zobrazit plný text záznamu Full text from SpringerLink