In cancer, A-to-I RNA editing can be the driver, the passenger, or the mechanic
| Autor: | Nabeel S. Ganem, Noa Ben-Asher, Ayelet T. Lamm |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Cancer Research Adenosine Protein family Adenosine Deaminase Carcinogenesis Alu element Antineoplastic Agents Computational biology Biology 03 medical and health sciences Alu Elements Neoplasms Biomarkers Tumor Humans Pharmacology (medical) Molecular Targeted Therapy RNA Messenger Gene RNA Double-Stranded Pharmacology Genetics Messenger RNA Tumor Suppressor Proteins RNA RNA-Binding Proteins Genetic Therapy Oncogenes Inosine RNA silencing 030104 developmental biology Infectious Diseases Oncology RNA editing ADAR RNA Editing |
| Zdroj: | Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy. 32 |
| ISSN: | 1532-2084 |
| Popis: | In recent years, A-to-I RNA modifications performed by the Adenosine Deaminase Acting on RNA (ADAR) protein family were found to be expressed at altered levels in multiple human malignancies. A-to-I RNA editing changes adenosine to inosine on double stranded RNA, thereby changing transcript sequence and structure. Although A-to-I RNA editing have the potential to change essential mRNA transcripts, affecting their corresponding protein structures, most of the human editing sites identified to date reside in non-coding repetitive transcripts such as Alu elements. Therefore, the impact of the hypo- or hyper-editing found in specific cancers remains unknown. Moreover, it is yet unclear whether or not changes in RNA editing and ADAR expression levels facilitate or even drive cancer progression or are just a byproduct of other affected pathways. In both cases, however, the levels of RNA editing and ADAR enzymes can possibly be used as specific biomarkers, as their levels change differently in specific malignancies. More significantly, recent studies suggest that ADAR enzymes can be used to reverse the oncogenic process, suggesting a potential for gene therapies. This review focuses on new findings that suggest that RNA editing by ADARs can affect cancer progression and even formation. We also discuss new possibilities of using ADAR enzymes and RNA editing as cancer biomarkers, indicators of chemotherapeutic drug sensitivity, and even to be themselves potential therapeutic tools. |
| Databáze: | OpenAIRE |
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