Abnormal myocardial blood flow in children with mild/moderate aortic stenosis
| Autor: | Erin J. Madriago, Daniel J. Woodward, Michael Jerosch-Herold, Ronald Wells, Michael Silberbach, Stephen M. Langley, Brian S. Diggs, David J. Sahn |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Adenosine Adolescent Heart Ventricles Contrast Media Asymptomatic Ventricular Function Left Coronary Circulation medicine.artery Internal medicine Ascending aorta medicine Humans Child business.industry Infant Aortic Valve Stenosis General Medicine Blood flow medicine.disease Stenosis medicine.anatomical_structure Ventricle Child Preschool Pediatrics Perinatology and Child Health Ventricular pressure Cardiology Female medicine.symptom Cardiology and Cardiovascular Medicine business Perfusion Blood Flow Velocity medicine.drug |
| Zdroj: | Cardiology in the Young. 25:1358-1366 |
| ISSN: | 1467-1107 1047-9511 |
| Popis: | ObjectiveTo quantify myocardial blood flow in infants and children with mild or moderate aortic stenosis using adenosine-infusion cardiac magnetic resonance.BackgroundIt is unclear whether asymptomatic children with mild/moderate aortic stenosis have myocardial abnormalities. In addition, cardiac magnetic resonance-determined normative myocardial blood flow data in children have not been reported.MethodsWe studied 31 infants and children with either haemodynamically normal hearts (n=20, controls) or mild/moderate aortic stenosis (n=11). The left ventricular myocardium was divided into six segments, and the change in average segmental signal intensity during contrast transit was used to quantify absolute flow (ml/g/minute) at rest and during adenosine infusion by deconvolution of the tissue curves with the arterial input of contrast.ResultsIn all the cases, adenosine was well tolerated without complications. The mean pressure gradient between the left ventricle and the ascending aorta was higher in the aortic stenosis group compared with controls (24 versus 3 mmHg, p2, pConclusionAbnormal myocardial blood flow in children with mild/moderate aortic stenosis may be an important therapeutic target. |
| Databáze: | OpenAIRE |
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