Psychosocial stress is associated with benign breast disease in young Chinese women: results from Project ELEFANT
| Autor: | Hongbin Liu, Ander Wilson, Timothy M. Barrow, Lilin Shen, Liqiong Guo, Peng-hui Li, Cheng Peng, Chanachai Sae-Lee, Hyang-Min Byun, Naijun Tang, Hao Wang |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
0301 basic medicine Cancer Research medicine.medical_specialty Adolescent Neutrophils Logistic regression Cohort Studies Breast Diseases 03 medical and health sciences 0302 clinical medicine Breast cancer Asian People Surveys and Questionnaires Internal medicine medicine Humans Lymphocyte Count Family history skin and connective tissue diseases Retrospective Studies sub_healthsciences Inflammation Social stress business.industry Incidence (epidemiology) Middle Aged medicine.disease Confidence interval 030104 developmental biology Oncology 030220 oncology & carcinogenesis Menarche Female Breast disease business sub_biomedicalsciences Biomarkers Stress Psychological |
| Zdroj: | Breast Cancer Research and Treatment. 173:217-224 |
| ISSN: | 1573-7217 0167-6806 |
| DOI: | 10.1007/s10549-018-4979-4 |
| Popis: | Purpose:\ud Psychosocial stress, including bereavement and work-related stress, is associated with the risk of breast cancer. However, it is unknown whether it may also be linked with increased risk of benign breast disease (BBD). \ud \ud Methods: \ud Our study leveraged 61,907 women aged 17-55 years-old from the Project ELEFANT study. BBD was diagnosed by clinician. Self-reported data on psychosocial stress over a ten-year period was retrospectively collected from questionnaires and categorised by cause (work, social and economic) and severity (none, low, and high). Odd ratios (ORs) for the development of BBD were estimated using logistic regression. The model was adjusted for age, BMI, TSH levels, smoking, alcohol consumption, family history, age of menarche, oral contraceptive usage, education and occupation.\ud \ud Results: \ud Within our study, 8% (4,914) of participants were diagnosed with BBD. Work-related stress (OR = 1.57, 95% confidence interval [CI] = 1.46 - 1.69) and financial stress (OR = 1.34, 95% CI = 1.24 - 1.44) were significantly associated with BBD incidence, with a smaller but still significant association with social stress (OR = 1.11, 95% CI = 1.01 - 1.21). The associations remained significant after exclusion of participants with first- and second-degree family history of breast disease. The presence of multiple forms of stress did not synergistically increase risk. The neutrophil lymphocyte ratio (NLR), a marker of systemic inflammation and prognostic marker for breast cancer, was not associated with BBD.\ud \ud Conclusions:\ud Psychosocial stress, particularly work-related and financial stress, is associated with increased risk of benign breast disease among young Chinese women. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink