Long noncoding RNAs in cancer: mechanisms of action and technological advancements
| Autor: | Nenad Bartonicek, Jesper L.V. Maag, Marcel E. Dinger |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Cancer Research Review Computational biology Biology medicine.disease_cause Bioinformatics Epigenesis Genetic 03 medical and health sciences RNA interference Neoplasms Biomarkers Tumor medicine Animals Humans Cancer biology Epigenesis Neovascularization Pathologic Gene Expression Profiling Cancer Lncrna expression medicine.disease Gene Expression Regulation Neoplastic Gene expression profiling Cell Transformation Neoplastic 030104 developmental biology The Hallmarks of Cancer Oncology Molecular Medicine RNA Interference RNA Long Noncoding Carcinogenesis Signal Transduction |
| Zdroj: | Molecular Cancer |
| ISSN: | 1476-4598 |
| Popis: | The previous decade has seen long non-coding RNAs (lncRNAs) rise from obscurity to being defined as a category of genetic elements, leaving its mark on the field of cancer biology. With the current number of curated lncRNAs increasing by 10,000 in the last five years, the field is moving from annotation of lncRNA expression in various tumours to understanding their importance in the key cancer signalling networks and characteristic behaviours. Here, we summarize the previously identified as well as recently discovered mechanisms of lncRNA function and their roles in the hallmarks of cancer. Furthermore, we identify novel technologies for investigation of lncRNA properties and their function in carcinogenesis, which will be important for their translation to the clinic as novel biomarkers and therapeutic targets. Electronic supplementary material The online version of this article (doi:10.1186/s12943-016-0530-6) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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