The association between the rs4987105 of 5-lipoxygenase (ALOX5) gene and gestational glucose metabolism in Chinese population

Autor: Liping Lai, Xi Li, Xiujie Zheng, Baojiang Wang, Shiguo Chen, Keqin Yao, Sheng Lin, Jindi Su, Shan Duan
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Blood Glucose
0301 basic medicine
endocrine system diseases
lcsh:Medicine
Gestational diabetes mellitus
0302 clinical medicine
Gene Frequency
Pregnancy
Risk Factors
Glucose homeostasis
ALOX5
lcsh:QH301-705.5
Confounding
General Medicine
Gestational diabetes
Research Note
Gestation
Female
Adult
China
medicine.medical_specialty
Genotype
030209 endocrinology & metabolism
Carbohydrate metabolism
Polymorphism
Single Nucleotide
General Biochemistry
Genetics and Molecular Biology
03 medical and health sciences
Asian People
Internal medicine
Genetic model
medicine
Genetic predisposition
Genetic susceptibility
Humans
Genetic Predisposition to Disease
Polymorphism
lcsh:Science (General)
Alleles
Arachidonate 5-Lipoxygenase
business.industry
lcsh:R
Fasting plasma glucose
Type 2 Diabetes Mellitus
nutritional and metabolic diseases
medicine.disease
Diabetes
Gestational
Glucose
030104 developmental biology
Endocrinology
lcsh:Biology (General)
business
lcsh:Q1-390
Zdroj: BMC Research Notes, Vol 13, Iss 1, Pp 1-5 (2020)
BMC Research Notes
ISSN: 1756-0500
Popis: Objective The arachidonate 5-lipoxygenase (ALOX5) pathway has been investigated in diverse chronic inflammatory diseases including metabolic disorders. Recently, the ALOX5 polymorphism rs4987105 was identified to confer susceptibility to type 2 diabetes mellitus (T2DM), implicating its role in regulating glucose homeostasis. Gestational diabetes mellitus (GDM) shares similar pathogenic mechanism with T2DM. Thus, we aimed to evaluate the association between rs4987105 and gestational glucose metabolism in Chinese pregnant women. Results A total of 380 unrelated Chinese pregnant women including 241 GDM patients and 139 controls were included in this study. The genotypes of rs4987105 were examined by the Agena MassARRAY iPLEX platform, the association between rs4987105 and fasting plasma glucose (FPG) levels at 24–28 gestational weeks was evaluated using different statistical methods. We found that carriers of rs4987105 CT/TT genotypes exhibited significantly lower FPG levels (P = 0.011). In addition, we observed a significant association between rs4987105 and FPG levels after adjusting confounding variables in the linear regression analysis using dominant genetic model (b = − 0.218; P = 0.01). The present study for the first time reported that the rs4987105 of 5-lipoxygenase (ALOX5) gene was associated with gestational glucose metabolism in Chinese pregnant women.
Databáze: OpenAIRE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje