Serial Doppler echocardiographic assessment of left and right ventricular filling for non-invasive diagnosis of mild acute cardiac allograft rejection
| Autor: | Karl Theisen, C. E. Angermann, Susanne D. Schnaack, Christoph H. Spes, J. M. Gokel, A. Schütz, Bernhard M. Kemkes |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
Graft Rejection Male medicine.medical_specialty Biopsy medicine.medical_treatment Doppler echocardiography Ventricular Function Left symbols.namesake Postoperative Complications Internal medicine medicine Humans Rejection (Psychology) Heart transplantation medicine.diagnostic_test Cardiac allograft business.industry Myocardium Hemodynamics Signal Processing Computer-Assisted Middle Aged Echocardiography Doppler Confidence interval Ventricular Function Right cardiovascular system symbols Cardiology Heart Transplantation Female Cardiology and Cardiovascular Medicine Complication Ventricular filling business Doppler effect Blood Flow Velocity Endocardium |
| Zdroj: | European Heart Journal. 13:889-894 |
| ISSN: | 1522-9645 0195-668X |
| DOI: | 10.1093/oxfordjournals.eurheartj.a060288 |
| Popis: | Detection of acute cardiac allograft rejection (AR) remains an important clinical challenge. The role of Doppler echocardiography for the non-invasive diagnosis of AR is controversial, in particular with regard to milder forms of rejection. This study was designed to evaluate the potential of Doppler echocardiography for the non-invasive diagnosis of mild AR. Serial measurements of left and right ventricular filling parameters were performed in 31 heart transplant recipients and compared with simultaneously obtained endomyocardial biopsies. To account for biological and technical variability, consecutive rejection-free studies were used to calculate 95% confidence limits for mitral and tricuspid maximum early flow velocity and pressure half time. Measurements obtained during mild AR were then compared to these data. The study demonstrated that all parameters varied considerably between consecutive rejection-free examinations. Changes in left and right ventricular filling parameters during mild A R rarely exceeded the calculated 95% confidence limits. Thus Doppler echocardiography appears of little value for the non-invasive diagnosis of mild acute cardiac rejection. |
| Databáze: | OpenAIRE |
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