Calibration and accuracy of the geno2pheno co-receptor algorithm for predicting HIV tropism for single and triplicate measurements of V3 genotype
| Autor: | David J.H.F. Knapp, LC Swenson, PR Harrigan |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
education.field_of_study
business.industry Population Public Health Environmental and Occupational Health medicine.disease chemistry.chemical_compound Infectious Diseases chemistry Acquired immunodeficiency syndrome (AIDS) Genotype HIV tropism Medicine Population study Oral Presentation False positive rate business education Algorithm Tropism Maraviroc |
| Zdroj: | Journal of the International AIDS Society |
| ISSN: | 1758-2652 |
| DOI: | 10.1186/1758-2652-13-s4-o8 |
| Popis: | Background: The geno2pheno algorithm (g2p) can give dichotomous tropism based on a selectable "false positive rate" (FPR), reflecting the proportion of individuals inappropriately called "non-R5" and falsely excluded from taking CCR5 antagonists. The effect of replicate genotype measures and different FPR values remains controversial. Here we characterize different FPR "cut-points" in predicting tropism for single vs multiple replicates for interpreting V3 genotype based on data from the clinical trials of Maraviroc (MVC) in experienced patients. Methods: The first study population comprised all patients screened for MOTIVATE 1 (N=1399; 44% non-R5 by original Trofile) for whom both triplicate and single V3 genotypes were available. We also examined virological response (defined as a week 8 decrease ≥2 logs and/or to |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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