Mechanics of caudal artery relaxation in control and hypertensive rats
| Autor: | Packer Cs, Stephens Nl |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Tail
Muscle tissue medicine.medical_specialty Contraction (grammar) Physiology Muscle Relaxation chemistry.chemical_element Isometric exercise Calcium Rats Inbred WKY Muscle Smooth Vascular Rats Inbred SHR Physiology (medical) Internal medicine Animals Medicine Caudal artery Pharmacology business.industry Relaxation (NMR) Rats Inbred Strains Arteries General Medicine Anatomy Biomechanical Phenomena Rats medicine.anatomical_structure chemistry Hypertension Time course Cardiology business Muscle Contraction Artery |
| Zdroj: | Canadian Journal of Physiology and Pharmacology. 63:209-213 |
| ISSN: | 1205-7541 0008-4212 |
| DOI: | 10.1139/y85-039 |
| Popis: | Alterations of smooth muscle function can just as easily stem from mechanical alterations in its ability to relax as from alteration in contraction. Since a failure of arterial smooth muscle to relax may contribute to the development of hypertension, we felt it necessary to study the relaxation process in greater depth. The effect of load on the time course of relaxation of rat caudal artery smooth muscle was analyzed either by comparing afterloaded contractions against various loads or by imposing abrupt alterations in load. Unlike mammalian striated muscles in which relaxation was reported sensitive to loading conditions, relaxation in the smooth muscle of the rat caudal artery (n = 17) was found to be largely independent of loading conditions. This type of relaxation has been termed "inactivation-dependent" relaxation; it is typical of muscle tissue in which the calcium sequestering apparatus is poorly developed. Our results suggest that calcium resequestration, or some biochemical process downstream to it, is the rate-limiting step during relaxation in arterial smooth muscle and that this is not qualitatively different for hypertensive arterial smooth muscle. These analytic techniques were used in the study of relaxation of hypertensive vessels. Quantitative analysis of the relaxation curves showed that both isometric and isotonic relaxation time was prolonged in hypertensive arterial smooth muscle. Prolonged isotonic relaxation indicates that hypertensive arteries remain narrowed for prolonged periods compared with normotensive vessels. Such narrowed vessels may be a factor in the increased total peripheral resistance seen in genetic hypertension. |
| Databáze: | OpenAIRE |
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