Elevated plasma levels of transforming growth factor-β1 in NIDDM
| Autor: | Cordula Drewes, Helmut Schatz, Andreas Pfeiffer, Kristina Middelberg-Bisping |
|---|---|
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Coronary Disease Statistics Nonparametric Diabetic Neuropathies Reference Values Transforming Growth Factor beta Internal medicine Diabetes mellitus Blood plasma Internal Medicine medicine Humans Diabetic Nephropathies Risk factor Aged Advanced and Specialized Nursing Glycated Hemoglobin Diabetic Retinopathy Vascular disease business.industry Middle Aged medicine.disease Pathophysiology Endocrinology Diabetes Mellitus Type 2 Metabolic control analysis Hypertension Regression Analysis Female business Biomarkers Diabetic Angiopathies Retinopathy Transforming growth factor |
| Zdroj: | Scopus-Elsevier |
| Popis: | OBJECTIVE Transforming growth factor-β (TGF-β) is a potent inducer of extracellular matrix production and of fibrogenesis and has been associated with the occurrence of diabetic micro- and macrovascular complications. Our aim was to determine whether circulating levels of TGF-β1 are altered in NIDDM and, if so, whether they are correlated with blood glucose and show an association with diabetic complications. RESEARCH DESIGN AND METHODS Plasma levels of TGF-β1 were determined by enzyme-linked immunosorbent assay in 44 NIDDM patients and 28 control subjects of comparable age and weight and were correlated with parameters of metabolic control and the occurrence of micro- and macrovascular complications. RESULTS TGF-β1 was significantly elevated in NIDDM (7.9 ± 1.0 ng/ml), as compared with control subjects (3.1 ± 0.4 ng/ml, P < 0.001) and correlated with glycosylated hemoglobin (r2 = 0.42; P < 0.001). Thrombocyte levels of TGF-β1 were similar in control subjects (54 ± 7 pg/ml, n = 16) and diabetic patients (61.6 ± 18 pg/ml, n = 13; P = 0.357). Elevated TGF-β1 levels were associated with retinopathy and neuropathy. CONCLUSIONS We conclude that plasma levels of TGF-β1 are elevated in NIDDM patients and may be related to average blood glucose. Preliminary data suggest that they may contribute to the occurrence of diabetic complications. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|