Acute reduction of brain substance P induced by nicotine
| Autor: | H. Maker, Abel Lajtha, J. Sleis, N. E. Naftchi, Susan E. Leeman, Evelyn P. Lapin |
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| Rok vydání: | 1988 |
| Předmět: |
Male
medicine.medical_specialty Nicotine Substance P Nucleus accumbens Mecamylamine Biochemistry Cellular and Molecular Neuroscience chemistry.chemical_compound Internal medicine Basal ganglia medicine Animals Chemistry Olfactory tubercle Brain Rats Inbred Strains General Medicine Rats Ventral tegmental area Kinetics Nicotinic agonist medicine.anatomical_structure Endocrinology Organ Specificity Anesthesia medicine.drug |
| Zdroj: | Neurochemical research. 13(4) |
| ISSN: | 0364-3190 |
| Popis: | Ten minutes after a single injection of 0.8 mg/kg nicotine SC (free base) the level of substance P-like immunoreactivity (SPLI) was reduced by 61–73% in rat caudate-putamen, nucleus accumbens, and olfactory tubercle, with smaller and not significant reductions in the frontal cortex, substantia nigra, and ventral tegmental area. The nicotinic receptor antagonist mecamylamine (1.0 mg/kg IP) prevented the reductions in SPLI. The rapidity and the degree of the changes in SPLI after nicotine exceed those previously reported for other agents and implicate substance P neurotransmission as a major component of nicotinic action. |
| Databáze: | OpenAIRE |
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