Risk of Thyroid Cancer in 1,504 Patients Referred for Thyroid Surgery with Assumed Benign Histology
| Autor: | Giedrius Lelkaitis, Jacob H. Rasmussen, Signe Buhl Gram, Christoffer Holst Hahn, Christian von Buchwald, J. Bentzen, Ulla Feldt-Rasmussen |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
education.field_of_study
medicine.medical_specialty medicine.diagnostic_test business.industry Endocrinology Diabetes and Metabolism Population Thyroid 030209 endocrinology & metabolism Malignancy medicine.disease Scintigraphy Surgery 03 medical and health sciences 0302 clinical medicine Fine-needle aspiration medicine.anatomical_structure 030220 oncology & carcinogenesis medicine Stage (cooking) business education Thyroid cancer Translational Thyroidology / Research Article Hormone |
| Zdroj: | European Thyroid Journal. 8:246-255 |
| ISSN: | 2235-0802 2235-0640 |
| DOI: | 10.1159/000500539 |
| Popis: | OBJECTIVES: The aims of this study were to report the risk of thyroid malignancy in cases of either benign fine-needle aspiration (FNA) or without FNA performed, and to investigate possible predictive factors for thyroid malignancy in a population with recent moderately low iodine intake. METHODS: All patients referred for thyroid surgery in a tertiary cancer centre between 2000 and 2016 were included (n = 3,703). After excluding cases indicating malignant histology, we included group 1: patients with benign FNA (n = 764), and group 2: patients without FNA (n = 740), leaving 1,504 eligible for further investigation. Information on age, gender, tracheal compression or dislocation, thyroid specimen weight, scintigraphy, ultrasound, medically treated thyrotoxicosis, serum stimulating thyroid hormone, indication for surgery, TNM classification, stage, and outcome were retrieved. RESULTS: The malignancy risk was 7.6% (58/764) in group 1 and 6.8% (50/740) in group 2. Patients with T2–4 tumours constituted 2.2% (33/1,504). In the combined groups, ultrasound verified that solitary solid tumour was predictive for malignancy (p = 0.01 by χ2, and OR = 1.69, p = 0.02 in multiple logistic regression). For group 1 patients, thyrotoxicosis (which in this case was medically treated) was a significant predictive factor for malignancy (p = 0.04). CONCLUSIONS: The risk of malignancy of 7.6% and 6.8% was high, considering that patients with malignant FNA, suspicious FNA, or clinical findings indicating malignancy were excluded, and 2.2% of these malignancies were stages T2–4. In cases with solitary solid tumour on ultrasound, the risk of malignancy should not be ignored, even with benign FNA. |
| Databáze: | OpenAIRE |
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