LRRK2 R1628P increases risk of Parkinson’s disease: replication evidence
| Autor: | Yi Zhao, R. Pavanni, R. Li, Hui-Qin Lim, Kumar M. Prakash, Louis C. Tan, Michelle Tang, Eng-King Tan, Stephanie Fook-Chong, Yuen Yih |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Risk China Heterozygote medicine.medical_specialty Parkinson's disease Genotype Disease Protein Serine-Threonine Kinases Biology Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Logistic regression Gastroenterology Internal medicine Genetic variation Genetics medicine Humans Genetic Predisposition to Disease Genetics (clinical) Aged Aged 80 and over Case-control study Genetic Variation Parkinson Disease Middle Aged medicine.disease LRRK2 Case-Control Studies Female Age of onset |
| Zdroj: | Human Genetics. 124:287-288 |
| ISSN: | 1432-1203 0340-6717 |
| DOI: | 10.1007/s00439-008-0544-2 |
| Popis: | We showed that the frequency of a LRRK2 variant (c.4883G > C, R1628P) was higher in Parkinson’s disease (PD) compared to controls (8.4 vs. 3.4%, P = 0.046, OR 2.5, 95% CI 1.1–5.6). In the multivariate logistic regression (with adjustments made for the effect of age, age of onset, and gender), the heterozygous R1628P genotype was associated with an increased risk of PD compared to controls (OR 3.3, 95% CI 1.4– 7.9, P = 0.007). We provided an independent confirmation that the R1628P variant increases the risk of PD among Chinese. |
| Databáze: | OpenAIRE |
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