Impact of antenatal corticosteroids on head circumference of full‐term newborns: A French multicenter cohort study

Autor: Franck Perrotin, Chloé Arthuis, Judith Couderchet, Caroline Diguisto, Françoise Vendittelli, Andrei S. Morgan, Olivier Rivière
Přispěvatelé: Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Service d'Obstétrique et Gynécologique [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS), Université Francois Rabelais [Tours], Service d'Obstétrique et de Gynécologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Elizabeth Garrett Anderson Institute for Womens' Health [Londres, Royaume-Uni], University College of London [London] (UCL), Groupe Hospitalier Hôpitaux Universitaires Paris Seine-Saint-Denis [Bobigny] (GH HUPSSD), AUDIPOG, Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Institut Pascal (IP), SIGMA Clermont (SIGMA Clermont)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), SIGMA Clermont (SIGMA Clermont)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
medicine.medical_specialty
Percentile
Cephalometry
Gestational Age
[SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics
Cohort Studies
03 medical and health sciences
Obstetric Labor
Premature
0302 clinical medicine
Adrenal Cortex Hormones
Pregnancy
medicine
Birth Weight
Humans
030212 general & internal medicine
ComputingMilieux_MISCELLANEOUS
Full Term
[SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics
030219 obstetrics & reproductive medicine
Obstetrics
business.industry
Infant
Newborn
Obstetrics and Gynecology
Gestational age
Organ Size
General Medicine
Confidence interval
3. Good health
Head circumference
Relative risk
Female
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
France
Birth length
business
Head
Cohort study
Zdroj: Acta Obstetricia et Gynecologica Scandinavica
Acta Obstetricia et Gynecologica Scandinavica, Wiley, 2020, 99 (9), pp.1147-1154. ⟨10.1111/aogs.13839⟩
Acta Obstetricia et Gynecologica Scandinavica, 2020, 99 (9), pp.1147-1154. ⟨10.1111/aogs.13839⟩
ISSN: 0001-6349
1600-0412
DOI: 10.1111/aogs.13839⟩
Popis: Introduction Our main objective was to evaluate whether antenatal corticosteroids increase the risk of small head circumference in children born at term. Secondary objectives were to evaluate whether they increase the risk of small birthweight and birth length among those children. Material and methods A historical cohort included 275 270 live term born children between 2000 and 2013 in 175 French maternity units. The rate of head circumference below the 5th percentile among children born at term and exposed to antenatal corticosteroids was compared with that of two unexposed groups: those children born at term whose mothers had an episode of threatened preterm labor without corticosteroids and those whose mothers had neither threatened preterm labor nor corticosteroids. The association between this treatment and head circumference was evaluated by calculating adjusted risk ratios (aRRs) and their 95% confidence intervals (CIs). The main outcome measure was a head circumference below the 5th percentile at birth, adjusted for sex, and gestational age according to the Pediatric, Obstetrics, and Gynecology Electronic Records Users Association (AUDIPOG) curves. Secondary outcomes were birthweight and birth length below the 5th percentile. Results The rate of head circumference below the 5th percentile was 5.8% (n = 3388) among children exposed to antenatal corticosteroids and 4.3% (n = 7077) and 4.6% (n = 198 462), respectively, for the two unexposed groups. After adjustment, the risk of having a head circumference below the 5th percentile did not differ between the exposed group and the two control groups (aRR 1.28, 95% confidence interval [CI] 0.97-1.69] and aRR 0.91, 95% CI 0.74-1.13). We did not find an association between antenatal corticosteroids and the rate of birthweight below the 5th percentile. Children exposed to antenatal corticosteroids had a higher risk of a birth length below the 5th percentile when compared with those not exposed to threatened preterm labor or corticosteroids. Conclusions We found no association between antenatal corticosteroids and increased risk of head circumference below the 5th percentile in children born at term.
Databáze: OpenAIRE
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