Evaluation of the bioactivity of influenza vaccine strains in vitro suggests that the introduction of new strains in the 2010 Southern Hemisphere Trivalent Influenza Vaccine is associated with adverse events
| Autor: | Milica Ng, Steve Rockman, Dorit Becher, Allison Dyson, Eugene Maraskovsky, Megan Barnden, Adriana Baz Morelli, Sandra Koernig, Mimi L.K. Tang, Martin J. Pearse |
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| Rok vydání: | 2014 |
| Předmět: |
Trivalent influenza vaccine
Influenza vaccine medicine.medical_treatment medicine.disease_cause Seizures Febrile Immune system Influenza A Virus H1N1 Subtype Immunology and Microbiology(all) Influenza Human medicine Influenza A virus Product Surveillance Postmarketing Humans NF-kappaB Immune response Adverse effect Child General Veterinary General Immunology and Microbiology business.industry Influenza A Virus H3N2 Subtype Australia NF-kappa B Public Health Environmental and Occupational Health Infant Febrile reactions Virology veterinary(all) Seasonal trivalent influenza vaccine Vaccination Influenza B virus Cytokine HEK293 Cells Infectious Diseases Immunization Paediatric Influenza Vaccines Adverse events Child Preschool Immunology Cytokines Molecular Medicine Chemokines business |
| Zdroj: | Vaccine. 32(30):3861-3868 |
| ISSN: | 0264-410X |
| DOI: | 10.1016/j.vaccine.2014.03.032 |
| Popis: | In Australia, during the 2010 Southern Hemisphere (SH) influenza season, there was an unexpected increase in post-marketing adverse event reports of febrile seizures (FS) in children under 5 years of age shortly after vaccination with the CSL trivalent influenza vaccine (CSL 2010 SH TIV) compared to previous CSL TIVs and other licensed 2010 SH TIVs. The present study describes the outcomes of a series of in vitro experiments directed at elucidating the root cause. The scientific investigations found that a subset of paediatric donors displayed elevated cytokine/chemokine responses to the CSL 2010 SH TIV but not to previous CSL TIVs nor other 2010 SH TIVs. The induction of elevated cytokines/chemokines in paediatric whole blood correlated with elevated NF-κB activation in a HEK293 cell reporter assay. The data indicate that the introduction of the B/Brisbane/60/2008 strain within the CSL manufacturing process (such as occurred in the preceding 2009/10 NH season) appears to have raised the pyrogenic potential of the CSL 2009/10 NH TIV but that this was insufficient to elicit FS in children |
| Databáze: | OpenAIRE |
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