The long and winding road to IgA deficiency: causes and consequences
| Autor: | D T Laura Vo Ngoc, Frans J. van Overveld, G.T. Rijkers, Lizette Krist |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Transmembrane Activator and CAML Interactor Protein Tumor Necrosis Factor Ligand Superfamily Member 13 Immunology Biology Gut flora 03 medical and health sciences B-Cell Activating Factor medicine Animals Humans Immunology and Allergy Genetic Predisposition to Disease B-cell activating factor Immunity Mucosal Gene Cyclophilin Immunodeficiency Genetics B-Lymphocytes Polymorphism Genetic Activator (genetics) Microbiota Precursor Cells B-Lymphoid IgA Deficiency biology.organism_classification medicine.disease Immunoglobulin Class Switching Transmembrane protein Immunoglobulin A 030104 developmental biology Immunoglobulin class switching Gene-Environment Interaction |
| Zdroj: | Expert Review of Clinical Immunology. 13:371-382 |
| ISSN: | 1744-8409 1744-666X |
| DOI: | 10.1080/1744666x.2017.1248410 |
| Popis: | The most common humoral immunodeficiency is IgA deficiency. One of the first papers addressing the cellular and molecular mechanisms underlying IgA deficiency indicated that immature IgA-positive B-lymphocytes are present in these patients. This suggests that the genetic background for IgA is still intact and that class switching can take place. At this moment, it cannot be ruled out that genetic as well as environmental factors are involved. Areas covered: A clinical presentation, the biological functions of IgA, and the management of IgA deficiency are reviewed. In some IgA deficient patients, a relationship with a loss-of-function mutation in the TACI (transmembrane activator and calcium-modulating cyclophilin ligand interaction) gene has been found. Many other genes also have been associated. Gut microbiota are an important environmental trigger for IgA synthesis. Expert commentary: Expression of IgA deficiency is due to both genetic and environmental factors and a role for gut microbiota cannot be excluded. |
| Databáze: | OpenAIRE |
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